Chemical and biological studies on human oxygenases

Chemical and biological studies on human oxygenases

<p>As depicted in Chapter I, 2-oxoglutarate- (2OG) dependent oxygenases are ubiquitous in living systems and display a wide range of cellular functions, spanning metabolism, transcription, and translation. Although functionally diverse, the 2OG oxygenases share a high degree of structural simi...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Thinnes, C, Dr Cyrille C. Thinnes
Beste egile batzuk:	Schofield, C
Formatua:	Thesis
Hizkuntza:	English
Argitaratua:	2014
Gaiak:	Chemical biology Chemistry & allied sciences Business Entrepreneurship Structural genomics Oncology Biophysical chemistry Science and technology (business & management) Marketing Physical Sciences Pharmacology Cell Biology (see also Plant sciences) Management Biochemistry Enzymes Life Sciences Genetics (life sciences) Polymers Amino acid and peptide chemistry Organic synthesis Synthetic organic chemistry Organic chemistry Business and Management Protein chemistry Chemical kinetics Computer aided molecular and material design Biology

Antzeko izenburuak

NMR studies on 2-oxoglutarate oxygenases
nork: Leung, IKH
Argitaratua: (2013)

Development of small molecule inhibitors of the bromodomain-histone interaction
nork: Rooney, TPC
Argitaratua: (2014)

Olefin metathesis for site-selective protein modification
nork: Lin, YA
Argitaratua: (2013)

Design and synthesis of myo-inositol (1,4,5)-trisphosphate receptor antagonists
nork: Ye, Y
Argitaratua: (2013)

A glycopore for bacterial sensing
nork: Shanley, SJ
Argitaratua: (2009)

Single-molecule chemistry studies with engineered alpha-hemolysin pores
nork: Hammerstein, A
Argitaratua: (2011)

Developing inhibitors of bromodomain-histone interactions
nork: Hewings, D
Argitaratua: (2014)

Interplay between 2-oxoglutarate oxygenases and cancer: studies on the aspartyl/asparaginyl-beta-hydroxylase
nork: Pfeffer, I
Argitaratua: (2014)

Peptide targeting by spontaneous isopeptide bond formation
nork: Zakeri, B, et al.
Argitaratua: (2011)

Kinetic and mechanistic studies of oxygen sensing Fe(II)/2-oxoglutarate dependent oxygenases
nork: Tarhonskaya, H
Argitaratua: (2014)

Synthesis of Mycobacterium tuberculosis ATP synthase inhibitors
nork: Pattarakiat, Seankongsuk
Argitaratua: (2022)

Studies on an N-terminal nucleophile hydrolase and enzymes of clavulanic acid biosynthesis
nork: Iqbal, A
Argitaratua: (2008)

Mechanistic and inhibition studies on gamma-butyrobetaine hydroxylase
nork: Rydzik, AM
Argitaratua: (2014)

Conformational control by intramolecular hydrogen bonding
nork: Luccarelli, J, et al.
Argitaratua: (2013)

Enzymatic and structural insights into the mycobacterial alkylhydroperoxide reductase subunit C and repurposing of an antimalaria compound inhibiting the mycobacterial cytochrome BCC oxidase for tuberculosis disease
nork: Chong, Sherilyn Shi Min
Argitaratua: (2020)

Asymmetric syntheses of β- and γ-amino acids
nork: Zammit, C
Argitaratua: (2015)

Aziridinations of tethered allenes
nork: Feast, GC
Argitaratua: (2011)

Alkaloids from transannular iodoaminations
nork: Brock, E
Argitaratua: (2012)

Versatile synthetic strategies towards the development of novel neuroblastoma inhibitors and their analogues
nork: Alishahi, S
Argitaratua: (2013)

Studies towards the stereoselective synthesis of alkenes
nork: Arif, T
Argitaratua: (2011)

Analysis of potassium (K+) efflux systems (Kef) as an antibiotic target in pathogenic bacteria
nork: Haslam, C
Argitaratua: (2019)

Exploring and exploiting selectivity in Rhodium-catalysed hydroacylation reactions
nork: Poingdestre, SJ
Argitaratua: (2012)

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis
nork: Hodgson, D, et al.
Argitaratua: (2008)

Enantiorecognition phenomena in asymmetric synthesis
nork: Yin, J, et al.
Argitaratua: (2011)

Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence.
nork: Donohoe, T, et al.
Argitaratua: (2011)

Reaction engineering for protein modification: tools for chemistry and biology
nork: Chalker, J
Argitaratua: (2011)

Design and synthesis of inositol phosphate-based probes
nork: Slowey, A
Argitaratua: (2013)

The synthesis of branched sugars and iminosugars
nork: Parry, LL
Argitaratua: (2011)

Asymmetric synthesis of α-alkylated aldehydes using chiral enamines
nork: Kaka, N, et al.
Argitaratua: (2008)

Towards the total synthesis of calyciphylline A-type Daphniphyllum alkaloids
nork: Michaelides, IN
Argitaratua: (2014)

Transition metal catalysed C-C bond formation via C-H functionalisation
nork: Truscott, FR
Argitaratua: (2012)

Palladium mediated allylic fluorination
nork: Hollingworth, C
Argitaratua: (2013)

Determining the structures of halogenated marine natural products by total synthesis
nork: Dyson, BS
Argitaratua: (2011)

Tandem catalytic processes involving Rhodium-catalysed intermolecular hydroacylation
nork: Lenden, P
Argitaratua: (2011)

Molecular dynamics simulation of the M2 helices within the nicotinic acetylcholine receptor transmembrane domain: structure and collective motions
Argitaratua: (2005)

Studies towards the total synthesis of manzamine A
nork: Hawkins, A
Argitaratua: (2013)

Palladium-catalysed cascade cyclisation of alkynyl silanes and studies towards rubriflordilactone A
nork: Cordonnier, M, et al.
Argitaratua: (2011)

The synthesis and biology of iminosugars and their precursors
nork: Ayers, B, et al.
Argitaratua: (2014)

Discovery, characterization, and applications of cysteine-rich peptides from medicinal plants
nork: Huang, Jiayi
Argitaratua: (2020)

Perylene-derived single-component organic nanoparticles with tunable emission : efficient anticancer drug carriers with real-time Monitoring of drug release
nork: Li, Xin, et al.
Argitaratua: (2014)