Chemical and biological studies on human oxygenases

Chemical and biological studies on human oxygenases

<p>As depicted in Chapter I, 2-oxoglutarate- (2OG) dependent oxygenases are ubiquitous in living systems and display a wide range of cellular functions, spanning metabolism, transcription, and translation. Although functionally diverse, the 2OG oxygenases share a high degree of structural simi...

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Bibliografische gegevens
Hoofdauteurs:	Thinnes, C, Dr Cyrille C. Thinnes
Andere auteurs:	Schofield, C
Formaat:	Thesis
Taal:	English
Gepubliceerd in:	2014
Onderwerpen:	Chemical biology Chemistry & allied sciences Business Entrepreneurship Structural genomics Oncology Biophysical chemistry Science and technology (business & management) Marketing Physical Sciences Pharmacology Cell Biology (see also Plant sciences) Management Biochemistry Enzymes Life Sciences Genetics (life sciences) Polymers Amino acid and peptide chemistry Organic synthesis Synthetic organic chemistry Organic chemistry Business and Management Protein chemistry Chemical kinetics Computer aided molecular and material design Biology

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NMR studies on 2-oxoglutarate oxygenases
door: Leung, IKH
Gepubliceerd in: (2013)

Development of small molecule inhibitors of the bromodomain-histone interaction
door: Rooney, TPC
Gepubliceerd in: (2014)

Olefin metathesis for site-selective protein modification
door: Lin, YA
Gepubliceerd in: (2013)

Design and synthesis of myo-inositol (1,4,5)-trisphosphate receptor antagonists
door: Ye, Y
Gepubliceerd in: (2013)

A glycopore for bacterial sensing
door: Shanley, SJ
Gepubliceerd in: (2009)

Single-molecule chemistry studies with engineered alpha-hemolysin pores
door: Hammerstein, A
Gepubliceerd in: (2011)

Developing inhibitors of bromodomain-histone interactions
door: Hewings, D
Gepubliceerd in: (2014)

Interplay between 2-oxoglutarate oxygenases and cancer: studies on the aspartyl/asparaginyl-beta-hydroxylase
door: Pfeffer, I
Gepubliceerd in: (2014)

Peptide targeting by spontaneous isopeptide bond formation
door: Zakeri, B, et al.
Gepubliceerd in: (2011)

Kinetic and mechanistic studies of oxygen sensing Fe(II)/2-oxoglutarate dependent oxygenases
door: Tarhonskaya, H
Gepubliceerd in: (2014)

Synthesis of Mycobacterium tuberculosis ATP synthase inhibitors
door: Pattarakiat, Seankongsuk
Gepubliceerd in: (2022)

Studies on an N-terminal nucleophile hydrolase and enzymes of clavulanic acid biosynthesis
door: Iqbal, A
Gepubliceerd in: (2008)

Mechanistic and inhibition studies on gamma-butyrobetaine hydroxylase
door: Rydzik, AM
Gepubliceerd in: (2014)

Conformational control by intramolecular hydrogen bonding
door: Luccarelli, J, et al.
Gepubliceerd in: (2013)

Enzymatic and structural insights into the mycobacterial alkylhydroperoxide reductase subunit C and repurposing of an antimalaria compound inhibiting the mycobacterial cytochrome BCC oxidase for tuberculosis disease
door: Chong, Sherilyn Shi Min
Gepubliceerd in: (2020)

Asymmetric syntheses of β- and γ-amino acids
door: Zammit, C
Gepubliceerd in: (2015)

Aziridinations of tethered allenes
door: Feast, GC
Gepubliceerd in: (2011)

Alkaloids from transannular iodoaminations
door: Brock, E
Gepubliceerd in: (2012)

Versatile synthetic strategies towards the development of novel neuroblastoma inhibitors and their analogues
door: Alishahi, S
Gepubliceerd in: (2013)

Studies towards the stereoselective synthesis of alkenes
door: Arif, T
Gepubliceerd in: (2011)

Analysis of potassium (K+) efflux systems (Kef) as an antibiotic target in pathogenic bacteria
door: Haslam, C
Gepubliceerd in: (2019)

Exploring and exploiting selectivity in Rhodium-catalysed hydroacylation reactions
door: Poingdestre, SJ
Gepubliceerd in: (2012)

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis
door: Hodgson, D, et al.
Gepubliceerd in: (2008)

Enantiorecognition phenomena in asymmetric synthesis
door: Yin, J, et al.
Gepubliceerd in: (2011)

Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence.
door: Donohoe, T, et al.
Gepubliceerd in: (2011)

Reaction engineering for protein modification: tools for chemistry and biology
door: Chalker, J
Gepubliceerd in: (2011)

Design and synthesis of inositol phosphate-based probes
door: Slowey, A
Gepubliceerd in: (2013)

The synthesis of branched sugars and iminosugars
door: Parry, LL
Gepubliceerd in: (2011)

Asymmetric synthesis of α-alkylated aldehydes using chiral enamines
door: Kaka, N, et al.
Gepubliceerd in: (2008)

Towards the total synthesis of calyciphylline A-type Daphniphyllum alkaloids
door: Michaelides, IN
Gepubliceerd in: (2014)

Transition metal catalysed C-C bond formation via C-H functionalisation
door: Truscott, FR
Gepubliceerd in: (2012)

Palladium mediated allylic fluorination
door: Hollingworth, C
Gepubliceerd in: (2013)

Determining the structures of halogenated marine natural products by total synthesis
door: Dyson, BS
Gepubliceerd in: (2011)

Tandem catalytic processes involving Rhodium-catalysed intermolecular hydroacylation
door: Lenden, P
Gepubliceerd in: (2011)

Molecular dynamics simulation of the M2 helices within the nicotinic acetylcholine receptor transmembrane domain: structure and collective motions
Gepubliceerd in: (2005)

Studies towards the total synthesis of manzamine A
door: Hawkins, A
Gepubliceerd in: (2013)

Palladium-catalysed cascade cyclisation of alkynyl silanes and studies towards rubriflordilactone A
door: Cordonnier, M, et al.
Gepubliceerd in: (2011)

The synthesis and biology of iminosugars and their precursors
door: Ayers, B, et al.
Gepubliceerd in: (2014)

Discovery, characterization, and applications of cysteine-rich peptides from medicinal plants
door: Huang, Jiayi
Gepubliceerd in: (2020)

Perylene-derived single-component organic nanoparticles with tunable emission : efficient anticancer drug carriers with real-time Monitoring of drug release
door: Li, Xin, et al.
Gepubliceerd in: (2014)