Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection.

The complement cascade defines an important link between the innate and the specific immune system. Here we show that mice deficient for the third component of complement (C3-/- mice) are highly susceptible to primary infection with influenza virus. C3-/- mice showed delayed viral clearance and incr...

Descrición completa

Detalles Bibliográficos
Main Authors: Kopf, M, Abel, B, Gallimore, A, Carroll, M, Bachmann, M
Formato: Journal article
Idioma:English
Publicado: 2002
_version_ 1826269956255252480
author Kopf, M
Abel, B
Gallimore, A
Carroll, M
Bachmann, M
author_facet Kopf, M
Abel, B
Gallimore, A
Carroll, M
Bachmann, M
author_sort Kopf, M
collection OXFORD
description The complement cascade defines an important link between the innate and the specific immune system. Here we show that mice deficient for the third component of complement (C3-/- mice) are highly susceptible to primary infection with influenza virus. C3-/- mice showed delayed viral clearance and increased viral titers in lung, whereas mice deficient for complement receptors CR1 and CR2 (Cr2-/- mice) cleared the infection normally. Priming of T-helper cells and cytotoxic T cells (CTLs) in lung-draining lymph nodes was reduced, and the recruitment into the lung of virus-specific CD4+ and CD8+ effector T cells producing interferon-gamma was severely impaired in C3-/- but not in Cr2-/- mice. Consequently, T-helper cell-dependent IgG responses were reduced in C3-/- mice but remained intact in Cr2-/- mice. These results demonstrate that complement induces specific immunity by promoting T-cell responses.
first_indexed 2024-03-06T21:33:20Z
format Journal article
id oxford-uuid:45679a27-e8db-4a31-ad57-54eb92aa965f
institution University of Oxford
language English
last_indexed 2024-03-06T21:33:20Z
publishDate 2002
record_format dspace
spelling oxford-uuid:45679a27-e8db-4a31-ad57-54eb92aa965f2022-03-26T15:07:38ZComplement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:45679a27-e8db-4a31-ad57-54eb92aa965fEnglishSymplectic Elements at Oxford2002Kopf, MAbel, BGallimore, ACarroll, MBachmann, MThe complement cascade defines an important link between the innate and the specific immune system. Here we show that mice deficient for the third component of complement (C3-/- mice) are highly susceptible to primary infection with influenza virus. C3-/- mice showed delayed viral clearance and increased viral titers in lung, whereas mice deficient for complement receptors CR1 and CR2 (Cr2-/- mice) cleared the infection normally. Priming of T-helper cells and cytotoxic T cells (CTLs) in lung-draining lymph nodes was reduced, and the recruitment into the lung of virus-specific CD4+ and CD8+ effector T cells producing interferon-gamma was severely impaired in C3-/- but not in Cr2-/- mice. Consequently, T-helper cell-dependent IgG responses were reduced in C3-/- mice but remained intact in Cr2-/- mice. These results demonstrate that complement induces specific immunity by promoting T-cell responses.
spellingShingle Kopf, M
Abel, B
Gallimore, A
Carroll, M
Bachmann, M
Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection.
title Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection.
title_full Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection.
title_fullStr Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection.
title_full_unstemmed Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection.
title_short Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection.
title_sort complement component c3 promotes t cell priming and lung migration to control acute influenza virus infection
work_keys_str_mv AT kopfm complementcomponentc3promotestcellprimingandlungmigrationtocontrolacuteinfluenzavirusinfection
AT abelb complementcomponentc3promotestcellprimingandlungmigrationtocontrolacuteinfluenzavirusinfection
AT gallimorea complementcomponentc3promotestcellprimingandlungmigrationtocontrolacuteinfluenzavirusinfection
AT carrollm complementcomponentc3promotestcellprimingandlungmigrationtocontrolacuteinfluenzavirusinfection
AT bachmannm complementcomponentc3promotestcellprimingandlungmigrationtocontrolacuteinfluenzavirusinfection