Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.

The 3D structures of human therapeutic targets are enabling for drug discovery. However, their purification and crystallization remain rate determining. In individual cases, ligands have been used to increase the success rate of protein purification and crystallization, but the broad applicability o...

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Detalles Bibliográficos
Main Authors: Vedadi, M, Niesen, F, Allali-Hassani, A, Fedorov, O, Finerty, P, Wasney, G, Yeung, R, Arrowsmith, C, Ball, L, Berglund, H, Hui, R, Marsden, B, Nordlund, P, Sundstrom, M, Weigelt, J, Edwards, A
Formato: Journal article
Idioma:English
Publicado: 2006

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