Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.

The 3D structures of human therapeutic targets are enabling for drug discovery. However, their purification and crystallization remain rate determining. In individual cases, ligands have been used to increase the success rate of protein purification and crystallization, but the broad applicability o...

书目详细资料
Main Authors:	Vedadi, M, Niesen, F, Allali-Hassani, A, Fedorov, O, Finerty, P, Wasney, G, Yeung, R, Arrowsmith, C, Ball, L, Berglund, H, Hui, R, Marsden, B, Nordlund, P, Sundstrom, M, Weigelt, J, Edwards, A
格式:	Journal article
语言:	English
出版:	2006

相似书籍

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.
由: Gileadi, O, et al.
出版: (2007)

Crystal structure and biophysical characterization of human GDP-D-mannose 4, 6-dehydratase
由: Vedadi, M, et al.
出版: (2004)

High-throughput structural characterisation of therapeutic protein targets.
由: Marsden, B, et al.
出版: (2006)

High-throughput structural characterisation of therapeutic protein targets
由: Marsden, B, et al.
出版: (2006)

Protein production and purification.
由: Gräslund, S, et al.
出版: (2008)

Structure of dystrophia myotonica protein kinase.
由: Elkins, J, et al.
出版: (2009)

Structure of dystrophia myotonica protein kinase.
由: Elkins, J, et al.
出版: (2009)

Structural studies of a four-MBT repeat protein MBTD1.
由: Jitka Eryilmaz, et al.
出版: (2009-10-01)

Photoreduction and validation of haem–ligand intermediate states in protein crystals by in situ single-crystal spectroscopy and diffraction
由: Demet Kekilli, et al.
出版: (2017-05-01)

Modification of the loops in the ligand-binding site turns avidin into a steroid-binding protein
由: Kulomaa Markku S, et al.
出版: (2011-06-01)

Amine landscaping to maximize protein-dye fluorescence and ultrastable protein-ligand interaction
由: Jacobsen, M, et al.
出版: (2017)

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12
由: Chen, Z, et al.
出版: (2020)

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12
由: Chen, Z, et al.
出版: (2020)

Composition of Overlapping Protein-Protein and Protein-Ligand Interfaces.
由: Ruzianisra Mohamed, et al.
出版: (2015-01-01)

Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions.
由: Ivan, T, et al.
出版: (2016)

WONKA: objective novel complex analysis for ensembles of protein-ligand structures
由: Bradley, A, et al.
出版: (2015)

High-throughput production of human proteins for crystallization: the SGC experience.
由: Savitsky, P, et al.
出版: (2010)

High-throughput production of human proteins for crystallization: the SGC experience.
由: Savitsky, P, et al.
出版: (2010)

A chemical probe for Tudor domain protein spindlin1 to investigate chromatin function
由: Fagan, V, et al.
出版: (2019)

The XChemExplorer graphical workflow tool for routine or large-scale protein-ligand structure determination
由: Krojer, T, et al.
出版: (2017)

graphDelta: MPNN Scoring Function for the Affinity Prediction of Protein–Ligand Complexes
由: Dmitry S. Karlov, et al.
出版: (2020-03-01)

3,5-Dimethylisoxazoles inhibit the bromodomain-histone protein-protein interaction
由: Hewings, D, et al.
出版: (2012)

Rearrangement of mitochondrial pyruvate dehydrogenase subunit dihydrolipoamide dehydrogenase protein–protein interactions by the MDM2 ligand nutlin-3
由: Way, L, et al.
出版: (2016)

Insights for the development of specific kinase inhibitors by targeted structural genomics.
由: Fedorov, O, et al.
出版: (2007)

Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.
由: Hassler, M, et al.
出版: (2007)

Protein modeling, ligand-protein docking, and visualization
由: Lu, Bai Fang
出版: (2010)

Bluues_cplx: Electrostatics at Protein–Protein and Protein–Ligand Interfaces
由: Miguel Angel Soler, et al.
出版: (2025-01-01)

The Cryptosporidium parvum kinome.
由: Artz, J, et al.
出版: (2011)

Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC.
由: Higgins, M, et al.
出版: (2004)

Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.
由: Melanie A Adams-Cioaba, et al.
出版: (2010-11-01)

Methyl probes in proteins for determining ligand binding mode in weak protein–ligand complexes
由: Biswaranjan Mohanty, et al.
出版: (2022-07-01)

Databases of ligand-binding pockets and protein-ligand interactions
由: Kristy A. Carpenter, et al.
出版: (2024-12-01)

The crystal structure of the Hazara virus nucleocapsid protein
由: Surtees, R, et al.
出版: (2015)

Combining Bioinformatics and Biophysics to Understand Protein-Protein and Protein-Ligand Interactions
由: Barry Honig
出版: (2002-01-01)

WONKA and OOMMPPAA – analysis of protein-ligand interaction data to direct Structure Based Drug Design
由: Deane, C, et al.
出版: (2017)

WONKA and OOMMPPAA - analysis of protein-ligand interaction data to direct Structure Based Drug Design
由: Deane, C, et al.
出版: (2016)

Ligand clouds around protein clouds: a scenario of ligand binding with intrinsically disordered proteins.
由: Fan Jin, et al.
出版: (2013-01-01)

Single-molecule DNA biosensors for protein and ligand detection.
由: Lymperopoulos, K, et al.
出版: (2010)

Using NMR to study protein-ligand interactions
由: Abboud, M
出版: (2016)

Exploiting ligand-protein conjugates to monitor ligand-receptor interactions.
由: Hirohito Haruki, et al.
出版: (2012-01-01)