Design and analysis of genome-wide association studies

Design and analysis of genome-wide association studies

Despite many years of effort, linkage and candidate gene association studies have yielded disappointingly few risk loci for common human diseases such as diabetes, auto-immune disorders and cancers. Large sample sizes, increased understanding of the patterns of correlation in genetic variation, and...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Barrett, J
Awduron Eraill:	Donnelly, P
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2008
Pynciau:	Mathematical genetics and bioinformatics (statistics) Genetics (life sciences)

Eitemau Tebyg

Gene x gene interactions in genome wide association studies
gan: Bhattacharya, K
Cyhoeddwyd: (2014)

Bayesian and frequentist methods and analyses of genome-wide association studies
gan: Vukcevic, D
Cyhoeddwyd: (2009)

An integrated genomic approach for the identification and analysis of single nucleotide polymorphisms that affect cancer in humans
gan: Repapi, E
Cyhoeddwyd: (2013)

Extensions of the case-control design in genome-wide association studies
gan: Loizides, C
Cyhoeddwyd: (2012)

Quantifying the underestimation of relative risks from genome-wide association studies
gan: Spencer, C, et al.
Cyhoeddwyd: (2011)

Large-scale genetic analysis of quantitative traits
gan: Randall, J, et al.
Cyhoeddwyd: (2012)

Application of the Neutral Indel Model to genome sequences for diverse metazoans
gan: Meader, S
Cyhoeddwyd: (2010)

The estimation of recombination rates from population genetic data
gan: Auton, A
Cyhoeddwyd: (2007)

Statistical challenges in the detection of mutation and variation using high throughput sequencing
gan: Pfeifer, S
Cyhoeddwyd: (2012)

Genome-wide DNaseI hypersensitive sites profiles in laboratory mouse strains by DNase-seq
gan: Hosseini, M
Cyhoeddwyd: (2013)

Imputation aided analysis of the association between autoimmune diseases and the MHC
gan: Moutsianas, L
Cyhoeddwyd: (2011)

A method for the identification of biological pathways
gan: Honti, F
Cyhoeddwyd: (2014)

Genome annotation and selectional analysis of viral evolution
gan: de Groot, S
Cyhoeddwyd: (2008)

Using phylogeny to improve genome-wide distant homology recognition
gan: Abeln, S, et al.
Cyhoeddwyd: (2007)

Statistical methods for the analysis of genetic association studies
gan: Su, Z
Cyhoeddwyd: (2008)

On genetic variants underlying common disease
gan: Hechter, E
Cyhoeddwyd: (2011)

Bayesian methods for multivariate phenotype analysis in genome-wide association studies
gan: Iotchkova, V
Cyhoeddwyd: (2013)

Bayesian methods for fine mapping in genetic association studies
gan: Frangou, E
Cyhoeddwyd: (2013)

Inferring the fine-scale structure and evolution of recombination from high-throughput genome sequencing
gan: Venn, O
Cyhoeddwyd: (2013)

Multilocus sequence analysis of the pathogen Neisseria meningitidis
gan: Wilson, D
Cyhoeddwyd: (2005)

Statistical HLA type imputation from large and heterogeneous datasets
gan: Dilthey, A
Cyhoeddwyd: (2012)

Comparative analysis of derived mutations across human populations.
gan: Feder, A, et al.
Cyhoeddwyd: (2013)

Exploring the fold space preferences of ancient and newborn protein superfamilies
gan: Edwards, H, et al.
Cyhoeddwyd: (2014)

Medical relevance and functional consequences of protein truncating variants
gan: Rivas Cruz, M
Cyhoeddwyd: (2015)

Statistical methods for mapping complex traits
gan: Allchin, L
Cyhoeddwyd: (2014)

LD-based SNP and genotype calling from next-generation sequencing reads.
gan: Menelaou, A
Cyhoeddwyd: (2012)

Probabilistic models of RNA secondary structure
gan: Anderson, JWJ
Cyhoeddwyd: (2013)

Statistical methods for genotype microarray data on large cohorts of individuals
gan: O'Connell, JM
Cyhoeddwyd: (2014)

The detection, structure and uses of extended haplotype identity in population genetic data
gan: Xifara, DK
Cyhoeddwyd: (2014)

Multiple sequence analysis in the presence of alignment uncertainty
gan: Herman, J, et al.
Cyhoeddwyd: (2014)

NucleoFinder: a statistical approach for the detection of nucleosome positions
gan: Becker, J, et al.
Cyhoeddwyd: (2013)

Bayesian methods for estimating human ancestry using whole genome SNP data
gan: Churchhouse, C
Cyhoeddwyd: (2012)

Protein fold evolution on completed genomes: distinguishing between young and old folds
gan: Abeln, S, et al.
Cyhoeddwyd: (2007)

Fold recognition and alignment in the ‘twilight zone’
gan: Hill, J, et al.
Cyhoeddwyd: (2013)

GAT: a simulation framework for testing the association of genomic intervals
gan: Heger, A, et al.
Cyhoeddwyd: (2013)

Whole-genome analysis of the transcriptional network underlying male sexual behaviour in Drosophila melanogaster
gan: Ashley, E, et al.
Cyhoeddwyd: (2012)

Accessing complex genomic variation in Plasmodium falciparum natural infections
gan: Wendler, J
Cyhoeddwyd: (2015)

Increasing statistical power and generalizability in genomics microarray research
gan: Ramasamy, A
Cyhoeddwyd: (2009)

The evolutionary dynamics of neutral networks: lessons from RNA
gan: Rendel, M
Cyhoeddwyd: (2008)

Statistical models for single-cell data
gan: Pierson, E
Cyhoeddwyd: (2015)