Design and analysis of genome-wide association studies

Design and analysis of genome-wide association studies

Despite many years of effort, linkage and candidate gene association studies have yielded disappointingly few risk loci for common human diseases such as diabetes, auto-immune disorders and cancers. Large sample sizes, increased understanding of the patterns of correlation in genetic variation, and...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखक:	Barrett, J
अन्य लेखक:	Donnelly, P
स्वरूप:	थीसिस
भाषा:	English
प्रकाशित:	2008
विषय:	Mathematical genetics and bioinformatics (statistics) Genetics (life sciences)

समान संसाधन

Gene x gene interactions in genome wide association studies
द्वारा: Bhattacharya, K
प्रकाशित: (2014)

Bayesian and frequentist methods and analyses of genome-wide association studies
द्वारा: Vukcevic, D
प्रकाशित: (2009)

An integrated genomic approach for the identification and analysis of single nucleotide polymorphisms that affect cancer in humans
द्वारा: Repapi, E
प्रकाशित: (2013)

Extensions of the case-control design in genome-wide association studies
द्वारा: Loizides, C
प्रकाशित: (2012)

Quantifying the underestimation of relative risks from genome-wide association studies
द्वारा: Spencer, C, और अन्य
प्रकाशित: (2011)

Large-scale genetic analysis of quantitative traits
द्वारा: Randall, J, और अन्य
प्रकाशित: (2012)

Application of the Neutral Indel Model to genome sequences for diverse metazoans
द्वारा: Meader, S
प्रकाशित: (2010)

The estimation of recombination rates from population genetic data
द्वारा: Auton, A
प्रकाशित: (2007)

Statistical challenges in the detection of mutation and variation using high throughput sequencing
द्वारा: Pfeifer, S
प्रकाशित: (2012)

Genome-wide DNaseI hypersensitive sites profiles in laboratory mouse strains by DNase-seq
द्वारा: Hosseini, M
प्रकाशित: (2013)

Imputation aided analysis of the association between autoimmune diseases and the MHC
द्वारा: Moutsianas, L
प्रकाशित: (2011)

A method for the identification of biological pathways
द्वारा: Honti, F
प्रकाशित: (2014)

Genome annotation and selectional analysis of viral evolution
द्वारा: de Groot, S
प्रकाशित: (2008)

Using phylogeny to improve genome-wide distant homology recognition
द्वारा: Abeln, S, और अन्य
प्रकाशित: (2007)

Statistical methods for the analysis of genetic association studies
द्वारा: Su, Z
प्रकाशित: (2008)

On genetic variants underlying common disease
द्वारा: Hechter, E
प्रकाशित: (2011)

Bayesian methods for multivariate phenotype analysis in genome-wide association studies
द्वारा: Iotchkova, V
प्रकाशित: (2013)

Bayesian methods for fine mapping in genetic association studies
द्वारा: Frangou, E
प्रकाशित: (2013)

Inferring the fine-scale structure and evolution of recombination from high-throughput genome sequencing
द्वारा: Venn, O
प्रकाशित: (2013)

Multilocus sequence analysis of the pathogen Neisseria meningitidis
द्वारा: Wilson, D
प्रकाशित: (2005)

Statistical HLA type imputation from large and heterogeneous datasets
द्वारा: Dilthey, A
प्रकाशित: (2012)

Comparative analysis of derived mutations across human populations.
द्वारा: Feder, A, और अन्य
प्रकाशित: (2013)

Exploring the fold space preferences of ancient and newborn protein superfamilies
द्वारा: Edwards, H, और अन्य
प्रकाशित: (2014)

Medical relevance and functional consequences of protein truncating variants
द्वारा: Rivas Cruz, M
प्रकाशित: (2015)

Statistical methods for mapping complex traits
द्वारा: Allchin, L
प्रकाशित: (2014)

LD-based SNP and genotype calling from next-generation sequencing reads.
द्वारा: Menelaou, A
प्रकाशित: (2012)

Probabilistic models of RNA secondary structure
द्वारा: Anderson, JWJ
प्रकाशित: (2013)

Statistical methods for genotype microarray data on large cohorts of individuals
द्वारा: O'Connell, JM
प्रकाशित: (2014)

The detection, structure and uses of extended haplotype identity in population genetic data
द्वारा: Xifara, DK
प्रकाशित: (2014)

Multiple sequence analysis in the presence of alignment uncertainty
द्वारा: Herman, J, और अन्य
प्रकाशित: (2014)

NucleoFinder: a statistical approach for the detection of nucleosome positions
द्वारा: Becker, J, और अन्य
प्रकाशित: (2013)

Bayesian methods for estimating human ancestry using whole genome SNP data
द्वारा: Churchhouse, C
प्रकाशित: (2012)

Protein fold evolution on completed genomes: distinguishing between young and old folds
द्वारा: Abeln, S, और अन्य
प्रकाशित: (2007)

Fold recognition and alignment in the ‘twilight zone’
द्वारा: Hill, J, और अन्य
प्रकाशित: (2013)

GAT: a simulation framework for testing the association of genomic intervals
द्वारा: Heger, A, और अन्य
प्रकाशित: (2013)

Whole-genome analysis of the transcriptional network underlying male sexual behaviour in Drosophila melanogaster
द्वारा: Ashley, E, और अन्य
प्रकाशित: (2012)

Accessing complex genomic variation in Plasmodium falciparum natural infections
द्वारा: Wendler, J
प्रकाशित: (2015)

Increasing statistical power and generalizability in genomics microarray research
द्वारा: Ramasamy, A
प्रकाशित: (2009)

The evolutionary dynamics of neutral networks: lessons from RNA
द्वारा: Rendel, M
प्रकाशित: (2008)

Statistical models for single-cell data
द्वारा: Pierson, E
प्रकाशित: (2015)