Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers.
BACKGROUND: We studied the effect of a single dose of a formulation of a methanolic extract of Hypericum perforatum (HP), also known as St. John's wort, on plasma concentrations of growth hormone (GH), prolactin (PRL), and cortisol (CORT) in 12 healthy male volunteers. METHODS: Subjects receive...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1999
|
| _version_ | 1826269973222260736 |
|---|---|
| author | Franklin, M Chi, J McGavin, C Hockney, R Reed, A Campling, G Whale, R Cowen, P |
| author_facet | Franklin, M Chi, J McGavin, C Hockney, R Reed, A Campling, G Whale, R Cowen, P |
| author_sort | Franklin, M |
| collection | OXFORD |
| description | BACKGROUND: We studied the effect of a single dose of a formulation of a methanolic extract of Hypericum perforatum (HP), also known as St. John's wort, on plasma concentrations of growth hormone (GH), prolactin (PRL), and cortisol (CORT) in 12 healthy male volunteers. METHODS: Subjects received 9 tablets of the finished product Jarsin 300 and placebo in a double-blind, balanced-order, cross-over design. RESULTS: Following HP relative to placebo, there was a significant increase in plasma GH and a significant decrease in plasma PRL. Plasma CORT levels were unchanged. CONCLUSIONS: Taken together with data from animal experimental studies, the findings suggest that this dose of HP may increase some aspects of brain dopamine function in humans. |
| first_indexed | 2024-03-06T21:33:35Z |
| format | Journal article |
| id | oxford-uuid:457c0b03-9d1c-4fd1-a62f-02362affe86d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:33:35Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:457c0b03-9d1c-4fd1-a62f-02362affe86d2022-03-26T15:08:05ZNeuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:457c0b03-9d1c-4fd1-a62f-02362affe86dEnglishSymplectic Elements at Oxford1999Franklin, MChi, JMcGavin, CHockney, RReed, ACampling, GWhale, RCowen, PBACKGROUND: We studied the effect of a single dose of a formulation of a methanolic extract of Hypericum perforatum (HP), also known as St. John's wort, on plasma concentrations of growth hormone (GH), prolactin (PRL), and cortisol (CORT) in 12 healthy male volunteers. METHODS: Subjects received 9 tablets of the finished product Jarsin 300 and placebo in a double-blind, balanced-order, cross-over design. RESULTS: Following HP relative to placebo, there was a significant increase in plasma GH and a significant decrease in plasma PRL. Plasma CORT levels were unchanged. CONCLUSIONS: Taken together with data from animal experimental studies, the findings suggest that this dose of HP may increase some aspects of brain dopamine function in humans. |
| spellingShingle | Franklin, M Chi, J McGavin, C Hockney, R Reed, A Campling, G Whale, R Cowen, P Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers. |
| title | Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers. |
| title_full | Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers. |
| title_fullStr | Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers. |
| title_full_unstemmed | Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers. |
| title_short | Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers. |
| title_sort | neuroendocrine evidence for dopaminergic actions of hypericum extract li 160 in healthy volunteers |
| work_keys_str_mv | AT franklinm neuroendocrineevidencefordopaminergicactionsofhypericumextractli160inhealthyvolunteers AT chij neuroendocrineevidencefordopaminergicactionsofhypericumextractli160inhealthyvolunteers AT mcgavinc neuroendocrineevidencefordopaminergicactionsofhypericumextractli160inhealthyvolunteers AT hockneyr neuroendocrineevidencefordopaminergicactionsofhypericumextractli160inhealthyvolunteers AT reeda neuroendocrineevidencefordopaminergicactionsofhypericumextractli160inhealthyvolunteers AT camplingg neuroendocrineevidencefordopaminergicactionsofhypericumextractli160inhealthyvolunteers AT whaler neuroendocrineevidencefordopaminergicactionsofhypericumextractli160inhealthyvolunteers AT cowenp neuroendocrineevidencefordopaminergicactionsofhypericumextractli160inhealthyvolunteers |