Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection.
Neutralizing (nAbs) and high affinity binding antibodies may be critical for an efficacious HIV-1 vaccine. We characterized virus-specific nAbs and binding antibody responses over 21 months in eight HIV-1 subtype C chronically infected individuals with heterogeneous rates of disease progression. Aut...
| প্রধান লেখক: | , , , , , , , , , , , , , , |
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| বিন্যাস: | Journal article |
| ভাষা: | English |
| প্রকাশিত: |
2012
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| _version_ | 1826269977305415680 |
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| author | Archary, D Rong, R Gordon, M Boliar, S Madiga, M Gray, E Dugast, A Hermanus, T Goulder, P Coovadia, H Werner, L Morris, L Alter, G Derdeyn, C Ndung'u, T |
| author_facet | Archary, D Rong, R Gordon, M Boliar, S Madiga, M Gray, E Dugast, A Hermanus, T Goulder, P Coovadia, H Werner, L Morris, L Alter, G Derdeyn, C Ndung'u, T |
| author_sort | Archary, D |
| collection | OXFORD |
| description | Neutralizing (nAbs) and high affinity binding antibodies may be critical for an efficacious HIV-1 vaccine. We characterized virus-specific nAbs and binding antibody responses over 21 months in eight HIV-1 subtype C chronically infected individuals with heterogeneous rates of disease progression. Autologous nAb titers of study exit plasma against study entry viruses were significantly higher than contemporaneous responses at study entry (p=0.002) and exit (p=0.01). NAb breadth and potencies against subtype C viruses were significantly higher than for subtype A (p=0.03 and p=0.01) or B viruses (p=0.03; p=0.05) respectively. Gp41-IgG binding affinity was higher than gp120-IgG (p=0.0002). IgG-FcγR1 affinity was significantly higher than FcγRIIIa (p<0.005) at study entry and FcγRIIb (p<0.05) or FcγRIIIa (p<0.005) at study exit. Evolving IgG binding suggests alteration of immune function mediated by binding antibodies. Evolution of nAbs was a potential marker of HIV-1 disease progression. |
| first_indexed | 2024-03-06T21:33:39Z |
| format | Journal article |
| id | oxford-uuid:4582deee-e1db-407d-a25a-4ed42cc65252 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:33:39Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:4582deee-e1db-407d-a25a-4ed42cc652522022-03-26T15:08:13ZCharacterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4582deee-e1db-407d-a25a-4ed42cc65252EnglishSymplectic Elements at Oxford2012Archary, DRong, RGordon, MBoliar, SMadiga, MGray, EDugast, AHermanus, TGoulder, PCoovadia, HWerner, LMorris, LAlter, GDerdeyn, CNdung'u, TNeutralizing (nAbs) and high affinity binding antibodies may be critical for an efficacious HIV-1 vaccine. We characterized virus-specific nAbs and binding antibody responses over 21 months in eight HIV-1 subtype C chronically infected individuals with heterogeneous rates of disease progression. Autologous nAb titers of study exit plasma against study entry viruses were significantly higher than contemporaneous responses at study entry (p=0.002) and exit (p=0.01). NAb breadth and potencies against subtype C viruses were significantly higher than for subtype A (p=0.03 and p=0.01) or B viruses (p=0.03; p=0.05) respectively. Gp41-IgG binding affinity was higher than gp120-IgG (p=0.0002). IgG-FcγR1 affinity was significantly higher than FcγRIIIa (p<0.005) at study entry and FcγRIIb (p<0.05) or FcγRIIIa (p<0.005) at study exit. Evolving IgG binding suggests alteration of immune function mediated by binding antibodies. Evolution of nAbs was a potential marker of HIV-1 disease progression. |
| spellingShingle | Archary, D Rong, R Gordon, M Boliar, S Madiga, M Gray, E Dugast, A Hermanus, T Goulder, P Coovadia, H Werner, L Morris, L Alter, G Derdeyn, C Ndung'u, T Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection. |
| title | Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection. |
| title_full | Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection. |
| title_fullStr | Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection. |
| title_full_unstemmed | Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection. |
| title_short | Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection. |
| title_sort | characterization of anti hiv 1 neutralizing and binding antibodies in chronic hiv 1 subtype c infection |
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