Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels.
Heteromultimerization between different inwardly rectifying (Kir) potassium channel subunits is an important mechanism for the generation of functional diversity. However, little is known about the mechanisms that control this process and that prevent promiscuous interactions in cells that express m...
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1826270005489041408 |
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| author | Konstas, A Korbmacher, C Tucker, S |
| author_facet | Konstas, A Korbmacher, C Tucker, S |
| author_sort | Konstas, A |
| collection | OXFORD |
| description | Heteromultimerization between different inwardly rectifying (Kir) potassium channel subunits is an important mechanism for the generation of functional diversity. However, little is known about the mechanisms that control this process and that prevent promiscuous interactions in cells that express many different Kir subunits. In this study, we have examined the heteromeric assembly of Kir5.1 with other Kir subunits and have shown that this subunit exhibits a highly selective interaction with members of the Kir4.0 subfamily and does not physically associate with other Kir subunits such as Kir1.1, Kir2.1, and Kir6.2. Furthermore, we have identified regions within the Kir4.1 subunit that appear to govern the specificity of this interaction. These results help us to understand the mechanisms that control Kir subunit recognition and assembly and how cells can express many different Kir channels while maintaining distinct subpopulations of homo- and heteromeric channels within the cell. |
| first_indexed | 2024-03-06T21:34:05Z |
| format | Journal article |
| id | oxford-uuid:45a6c93c-9139-4333-aca8-bf255cd81f4e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:34:05Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:45a6c93c-9139-4333-aca8-bf255cd81f4e2022-03-26T15:09:06ZIdentification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:45a6c93c-9139-4333-aca8-bf255cd81f4eEnglishSymplectic Elements at Oxford2003Konstas, AKorbmacher, CTucker, SHeteromultimerization between different inwardly rectifying (Kir) potassium channel subunits is an important mechanism for the generation of functional diversity. However, little is known about the mechanisms that control this process and that prevent promiscuous interactions in cells that express many different Kir subunits. In this study, we have examined the heteromeric assembly of Kir5.1 with other Kir subunits and have shown that this subunit exhibits a highly selective interaction with members of the Kir4.0 subfamily and does not physically associate with other Kir subunits such as Kir1.1, Kir2.1, and Kir6.2. Furthermore, we have identified regions within the Kir4.1 subunit that appear to govern the specificity of this interaction. These results help us to understand the mechanisms that control Kir subunit recognition and assembly and how cells can express many different Kir channels while maintaining distinct subpopulations of homo- and heteromeric channels within the cell. |
| spellingShingle | Konstas, A Korbmacher, C Tucker, S Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels. |
| title | Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels. |
| title_full | Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels. |
| title_fullStr | Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels. |
| title_full_unstemmed | Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels. |
| title_short | Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels. |
| title_sort | identification of domains that control the heteromeric assembly of kir5 1 kir4 0 potassium channels |
| work_keys_str_mv | AT konstasa identificationofdomainsthatcontroltheheteromericassemblyofkir51kir40potassiumchannels AT korbmacherc identificationofdomainsthatcontroltheheteromericassemblyofkir51kir40potassiumchannels AT tuckers identificationofdomainsthatcontroltheheteromericassemblyofkir51kir40potassiumchannels |