Structure and mechanism of the oestrogen receptor.

We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex pharmacological properties and how...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Kong, E, Pike, A, Hubbard, R
Format:	Journal article
Sprache:	English
Veröffentlicht:	2003

Beschreibung
Zusammenfassung:	We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex pharmacological properties and how the conformation of the receptor modulates its ability to recruit co-regulators that are necessary for transcriptional activation.

Structure and mechanism of the oestrogen receptor.

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