Genetics of gene expression in immunity to infection.
Mapping gene expression as a quantitative trait (eQTL mapping) can reveal local and distant associations with functionally important genetic variation informative for disease. Recent studies are reviewed which have demonstrated that this approach is particularly informative when applied to diverse i...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2014
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| _version_ | 1826270045057056768 |
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| author | Fairfax, B Knight, J |
| author_facet | Fairfax, B Knight, J |
| author_sort | Fairfax, B |
| collection | OXFORD |
| description | Mapping gene expression as a quantitative trait (eQTL mapping) can reveal local and distant associations with functionally important genetic variation informative for disease. Recent studies are reviewed which have demonstrated that this approach is particularly informative when applied to diverse immune cell populations and situations relevant to infection and immunity. Context-specific eQTL have now been characterised following endotoxin activation, induction with interferons, mycobacteria, and influenza, together with genetic determinants of response to vaccination. The application of genetical genomic approaches offers new opportunities to advance our understanding of gene-environment interactions and fundamental processes in innate and adaptive immunity. |
| first_indexed | 2024-03-06T21:34:42Z |
| format | Journal article |
| id | oxford-uuid:45d64305-2011-4118-ba59-9fa3e2d5abc7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:34:42Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:45d64305-2011-4118-ba59-9fa3e2d5abc72022-03-26T15:10:13ZGenetics of gene expression in immunity to infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:45d64305-2011-4118-ba59-9fa3e2d5abc7EnglishSymplectic Elements at OxfordElsevier2014Fairfax, BKnight, JMapping gene expression as a quantitative trait (eQTL mapping) can reveal local and distant associations with functionally important genetic variation informative for disease. Recent studies are reviewed which have demonstrated that this approach is particularly informative when applied to diverse immune cell populations and situations relevant to infection and immunity. Context-specific eQTL have now been characterised following endotoxin activation, induction with interferons, mycobacteria, and influenza, together with genetic determinants of response to vaccination. The application of genetical genomic approaches offers new opportunities to advance our understanding of gene-environment interactions and fundamental processes in innate and adaptive immunity. |
| spellingShingle | Fairfax, B Knight, J Genetics of gene expression in immunity to infection. |
| title | Genetics of gene expression in immunity to infection. |
| title_full | Genetics of gene expression in immunity to infection. |
| title_fullStr | Genetics of gene expression in immunity to infection. |
| title_full_unstemmed | Genetics of gene expression in immunity to infection. |
| title_short | Genetics of gene expression in immunity to infection. |
| title_sort | genetics of gene expression in immunity to infection |
| work_keys_str_mv | AT fairfaxb geneticsofgeneexpressioninimmunitytoinfection AT knightj geneticsofgeneexpressioninimmunitytoinfection |