Hypoxia regulates endogenous double-stranded RNA production via reduced mitochondrial DNA transcription

Hypoxia regulates endogenous double-stranded RNA production via reduced mitochondrial DNA transcription

Hypoxia is a common phenomenon in solid tumours strongly linked to the hallmarks of cancer. Hypoxia promotes local immunosuppression and downregulates type I interferon (IFN) expression and signalling, which contribute to the success of many cancer therapies. Double-stranded RNA (dsRNA), transiently...

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Bibliographic Details
Main Authors:	Arnaiz, E, Miar, A, Dias Junior, AG, Prasad, N, Schulze, U, Waithe, D, Nathan, JA, Rehwinkel, J, Harris, AL
Format:	Journal article
Language:	English
Published:	Frontiers 2021

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