Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines.

Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines.

CD8(+) T cell-numbers rapidly expand and then contract after exposure to their cognate antigen. Here we show that the sustained frequencies of transgene product-specific CD8(+) T cells elicited by replication-defective adenovirus vectors are linked to persistence of low levels of transcriptionally a...

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Bibliographic Details
Main Authors: Tatsis, N, Fitzgerald, J, Reyes-Sandoval, A, Harris-McCoy, K, Hensley, SE, Zhou, D, Lin, S, Bian, A, Xiang, Z, Iparraguirre, A, Lopez-Camacho, C, Wherry, E, Ertl, H
Format: Journal article
Language:English
Published: 2007

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