Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns.
BACKGROUND: Apolipoproteins B (apoB) and AI (apoAI) are strong predictors of cardiovascular disease (CVD). We describe apolipoprotein distributions and their associations with lipids and diabetes subtype in diabetic young adult South Asians. METHODS: In 995 subjects with diabetes, we measured fasti...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797065902117617664 |
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| author | Katulanda, G Katulanda, P Adler, A Peiris, SR Draisey, I Wijeratne, S Sheriff, R Matthews, DR Shine, B |
| author_facet | Katulanda, G Katulanda, P Adler, A Peiris, SR Draisey, I Wijeratne, S Sheriff, R Matthews, DR Shine, B |
| author_sort | Katulanda, G |
| collection | OXFORD |
| description | BACKGROUND: Apolipoproteins B (apoB) and AI (apoAI) are strong predictors of cardiovascular disease (CVD). We describe apolipoprotein distributions and their associations with lipids and diabetes subtype in diabetic young adult South Asians. METHODS: In 995 subjects with diabetes, we measured fasting total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), triglycerides (TG), apoB and apoAI, glycosylated haemoglobin (HbA1c) and glutamic acid decarboxylase antibodies (GADA). Low-density lipoprotein cholesterol (LDLC) and non-HDLC (NHDLC) were calculated. We compared values in subjects aged 15-50 y from the United States National Health and Nutrition Examination Survey (NHANES). RESULTS: Median age and duration of diabetes were 38 (range 14-45) and 4 (0-24) y. Men had significantly higher TC, TG, NHDLC, TC/HDLC, apoB/AI and NHDLC/apoB, and lower apoAI than women. Compared with the reference group, patients with type 1 diabetes had lower TG, apoB:apoAI and HDLC:apoAI, and higher HDLC and apoAI. Patients with type 2 diabetes had higher TG, TC, LDLC, NHDLC, TC:HDL, apoB, apoAI and apoB:apoAI, and lower HDLC, LDLC:apoB and HDLC:apoAI. Among patients with type 2 diabetes, 54% had high apoB (>1.2 g/L) and 33% also had high TG (>1.5 mmol/L). Measures of obesity (body mass index and waist circumference) were weakly correlated with lipid and apoprotein parameters, suggesting a modest contribution to dyslipidaemia. CONCLUSIONS: A large proportion of young adult Sri Lankan patients with type 2 diabetes has a low LDLC:apoB and high apoB and/or TG, suggesting that these patients are at increased risk of CVD. |
| first_indexed | 2024-03-06T21:34:58Z |
| format | Journal article |
| id | oxford-uuid:45ebda6c-f311-43b2-bf66-9cf393a426f2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:34:58Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:45ebda6c-f311-43b2-bf66-9cf393a426f22022-03-26T15:10:41ZApolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:45ebda6c-f311-43b2-bf66-9cf393a426f2EnglishSymplectic Elements at Oxford2010Katulanda, GKatulanda, PAdler, APeiris, SRDraisey, IWijeratne, SSheriff, RMatthews, DRShine, B BACKGROUND: Apolipoproteins B (apoB) and AI (apoAI) are strong predictors of cardiovascular disease (CVD). We describe apolipoprotein distributions and their associations with lipids and diabetes subtype in diabetic young adult South Asians. METHODS: In 995 subjects with diabetes, we measured fasting total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), triglycerides (TG), apoB and apoAI, glycosylated haemoglobin (HbA1c) and glutamic acid decarboxylase antibodies (GADA). Low-density lipoprotein cholesterol (LDLC) and non-HDLC (NHDLC) were calculated. We compared values in subjects aged 15-50 y from the United States National Health and Nutrition Examination Survey (NHANES). RESULTS: Median age and duration of diabetes were 38 (range 14-45) and 4 (0-24) y. Men had significantly higher TC, TG, NHDLC, TC/HDLC, apoB/AI and NHDLC/apoB, and lower apoAI than women. Compared with the reference group, patients with type 1 diabetes had lower TG, apoB:apoAI and HDLC:apoAI, and higher HDLC and apoAI. Patients with type 2 diabetes had higher TG, TC, LDLC, NHDLC, TC:HDL, apoB, apoAI and apoB:apoAI, and lower HDLC, LDLC:apoB and HDLC:apoAI. Among patients with type 2 diabetes, 54% had high apoB (>1.2 g/L) and 33% also had high TG (>1.5 mmol/L). Measures of obesity (body mass index and waist circumference) were weakly correlated with lipid and apoprotein parameters, suggesting a modest contribution to dyslipidaemia. CONCLUSIONS: A large proportion of young adult Sri Lankan patients with type 2 diabetes has a low LDLC:apoB and high apoB and/or TG, suggesting that these patients are at increased risk of CVD. |
| spellingShingle | Katulanda, G Katulanda, P Adler, A Peiris, SR Draisey, I Wijeratne, S Sheriff, R Matthews, DR Shine, B Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns. |
| title | Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns. |
| title_full | Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns. |
| title_fullStr | Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns. |
| title_full_unstemmed | Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns. |
| title_short | Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns. |
| title_sort | apolipoproteins in diabetes dyslipidaemia in south asians with young adult onset diabetes distribution associations and patterns |
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