Intervention methods against mosquito-borne diseases
<p>Mosquito-borne diseases account for hundreds of thousands of deaths each year, highlighting the need for successful intervention methods, which can be targeted at either the pathogen, mosquito vector, or human host. This thesis aims to contribute to better intervention methods focused again...
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| Format: | Thesis |
| Language: | English |
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2017
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| _version_ | 1817932975890759680 |
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| author | Blight, J |
| author2 | Reyes-Sandoval, A |
| author_facet | Reyes-Sandoval, A Blight, J |
| author_sort | Blight, J |
| collection | OXFORD |
| description | <p>Mosquito-borne diseases account for hundreds of thousands of deaths each year, highlighting the need for successful intervention methods, which can be targeted at either the pathogen, mosquito vector, or human host. This thesis aims to contribute to better intervention methods focused against malaria and dengue by either (i) improving available research tools, (ii) enhancing the understanding of a promising intervention method or (iii) designing new intervention candidates. Firstly, a superior method for studying <em>in vitro</em> malaria infection of the liver is shown, with implications for vaccine and drug interventions. Secondly, the biology of <em>Wolbachia</em> infection in <em>Anopheles gambiae</em> mosquitoes in the context of the target of rapamycin signalling cascade is investigated in an attempt to improve our understanding of its malaria inhibitory phenotype and inability to stably infect <em>An. gambiae</em> mosquitoes. Finally, an algorithm is developed for the design of a hypothesis driven conservation-based vaccine against viral mosquito diseases with a particular focus on dengue.</p> |
| first_indexed | 2024-03-06T21:35:02Z |
| format | Thesis |
| id | oxford-uuid:45f39b22-5393-4d29-afe1-580c16d530d6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:46:28Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | oxford-uuid:45f39b22-5393-4d29-afe1-580c16d530d62024-12-08T08:56:42ZIntervention methods against mosquito-borne diseasesThesishttp://purl.org/coar/resource_type/c_db06uuid:45f39b22-5393-4d29-afe1-580c16d530d6Communicable diseasesEnglishORA Deposit2017Blight, JReyes-Sandoval, ASinkins, S<p>Mosquito-borne diseases account for hundreds of thousands of deaths each year, highlighting the need for successful intervention methods, which can be targeted at either the pathogen, mosquito vector, or human host. This thesis aims to contribute to better intervention methods focused against malaria and dengue by either (i) improving available research tools, (ii) enhancing the understanding of a promising intervention method or (iii) designing new intervention candidates. Firstly, a superior method for studying <em>in vitro</em> malaria infection of the liver is shown, with implications for vaccine and drug interventions. Secondly, the biology of <em>Wolbachia</em> infection in <em>Anopheles gambiae</em> mosquitoes in the context of the target of rapamycin signalling cascade is investigated in an attempt to improve our understanding of its malaria inhibitory phenotype and inability to stably infect <em>An. gambiae</em> mosquitoes. Finally, an algorithm is developed for the design of a hypothesis driven conservation-based vaccine against viral mosquito diseases with a particular focus on dengue.</p> |
| spellingShingle | Communicable diseases Blight, J Intervention methods against mosquito-borne diseases |
| title | Intervention methods against mosquito-borne diseases |
| title_full | Intervention methods against mosquito-borne diseases |
| title_fullStr | Intervention methods against mosquito-borne diseases |
| title_full_unstemmed | Intervention methods against mosquito-borne diseases |
| title_short | Intervention methods against mosquito-borne diseases |
| title_sort | intervention methods against mosquito borne diseases |
| topic | Communicable diseases |
| work_keys_str_mv | AT blightj interventionmethodsagainstmosquitobornediseases |