Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly.

IL-12p40 partners with the p35 and p19 polypeptides to generate the heterodimeric cytokines IL-12 and IL-23, respectively. These cytokines play critical and distinct roles in host defense. The assembly of these heterodimers is thought to take place within the cell, resulting in the secretion of full...

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গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Abdi, K, Singh, N, Spooner, E, Kessler, B, Radaev, S, Lantz, L, Xiao, T, Matzinger, P, Sun, P, Ploegh, H
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: American Association of Immunologists 2014

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