Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly.

Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly.

IL-12p40 partners with the p35 and p19 polypeptides to generate the heterodimeric cytokines IL-12 and IL-23, respectively. These cytokines play critical and distinct roles in host defense. The assembly of these heterodimers is thought to take place within the cell, resulting in the secretion of full...

Bibliografske podrobnosti
Main Authors:	Abdi, K, Singh, N, Spooner, E, Kessler, B, Radaev, S, Lantz, L, Xiao, T, Matzinger, P, Sun, P, Ploegh, H
Format:	Journal article
Jezik:	English
Izdano:	American Association of Immunologists 2014

Podobne knjige/članki

IL-12p40 Monomer: A Potential Player in Macrophage Regulation
od: Brian Jeong, et al.
Izdano: (2024-02-01)

IL-15 promotes polyfunctional NK cell responses to influenza by boosting IL-12 production
od: Wagstaffe, HR, et al.
Izdano: (2018)

Inhibition of IL-12 heterodimers impairs TLR9-mediated prevention of early mouse plasmacytoma cell growth
od: Mohamed F. Mandour, et al.
Izdano: (2023-01-01)

1214 IL-12 vectors engineered to encode a functional p35-p40 heterodimer or a single p35 subunit for cancer immunotherapy
od: Robert Johnson, et al.
Izdano: (2023-11-01)

A new obligate CXCL4–CXCL12 heterodimer for studying chemokine heterodimer activities and mechanisms
od: Khanh T.P. Nguyen, et al.
Izdano: (2022-10-01)

CD40 agonist-induced IL-12p40 potentiates hepatotoxicity
od: Wei Chen, et al.
Izdano: (2020-05-01)

Highly Aromatic Norditerpenoid Heterodimers and Monomers from Trigonostemon fragilis
od: Jun-Su Zhou, et al.
Izdano: (2024-07-01)

Regression of Triple-Negative Breast Cancer in a Patient-Derived Xenograft Mouse Model by Monoclonal Antibodies against IL-12 p40 Monomer
od: Madhuchhanda Kundu, et al.
Izdano: (2022-01-01)

Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27
od: Mingli Xu, et al.
Izdano: (2010-01-01)

The Impact of Genetic Variants in IL-10 and IL-12p40 on the Susceptibility to Non Hodgkin Lymphoma
od: Mayasa Abdulla Ali, et al.
Izdano: (2019-06-01)

The level of cytokines IL-4, IL-12p40, IFN-y during acute toxoplasmosis
od: Dina A. Abdullah, et al.
Izdano: (2012-01-01)

The Impact of Genetic Variants in IL-10 and IL-12p40 on the Susceptibility to Non Hodgkin Lymphoma
od: Mayasa Abdulla Ali, et al.
Izdano: (2019-06-01)

IL-12/IL-23p40 identified as a downstream target of apremilast in models of arthritis
od: Tue W. Kragstrup, et al.
Izdano: (2019-02-01)

Aptameric Probe Specifically Binding Protein Heterodimer Rather Than Monomers
od: Tao Bing, et al.
Izdano: (2019-06-01)

The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation.
od: Gaëlle Chognard, et al.
Izdano: (2014-01-01)

Toll-like receptors differentially induce nucleosome remodelling at the IL-12p40 promoter
od: Tapmeier, T, et al.
Izdano: (2004)

Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression <it>in vivo</it>
od: Flynn Marion A, et al.
Izdano: (2004-10-01)

Novel TCF4:TCF12 heterodimer inhibits glioblastoma growth
od: Svetlana A. Mikheeva, et al.
Izdano: (2024-03-01)

IL-12B Promoter Polymorphism Associated with Asthma and IL-12B Transcriptional Activity
od: Koji Tatebayashi, et al.
Izdano: (2005-01-01)

IL-17 cytokines preferentially act on naïve CD4+ T cells with the IL-17AF heterodimer inducing the greatest functional changes.
od: Michael P Crawford, et al.
Izdano: (2023-01-01)

IL-12p40 deletion aggravates lipopolysaccharide-induced cardiac dysfunction in mice
od: Menglin Liu, et al.
Izdano: (2022-09-01)

Serum Levels of TNF-α, IL-12/23p40, and IL-17 in Plaque Psoriasis and Their Correlation with Disease Severity
od: Aikaterini Kyriakou, et al.
Izdano: (2014-01-01)

Elevated levels of IL-12/IL-23p40 in Nova Scotia Duck Tolling Retrievers with autoimmune disease and lymphoma
od: Malin Nilsson, et al.
Izdano: (2024-05-01)

Ebola virus protein VP40 stimulates IL-12– and IL-18–dependent activation of human natural killer cells
od: Hung Le, et al.
Izdano: (2022-08-01)

Cerebrospinal fluid IL-12p40, CXCL13 and IL-8 as a combinatorial biomarker of active intrathecal inflammation.
od: Bibiana Bielekova, et al.
Izdano: (2012-01-01)

Increased production of IL-4 and IL-12p40 from bronchoalveolar lavage cells are biomarkers of Mycobacterium tuberculosis in the sputum.
od: Anna Nolan, et al.
Izdano: (2013-01-01)

Evaluation of Salivary Interleukin 2 (IL-2) and Interleukin 12(IL-12) in Recurrent Aphthous Stomatitis
od: Sura Farhan Saeed, et al.
Izdano: (2024-10-01)

IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS
od: Peng, Judy C., et al.
Izdano: (2006)

A small non-interface surface epitope in human IL18 mediates the dynamics and self-assembly of IL18-IL18BP heterodimers
od: Yılmaz Yücehan Yazıcı, et al.
Izdano: (2023-01-01)

The Role of Interleukin-1 cytokine family (IL-1β, IL-37) and interleukin-12 cytokine family (IL-12, IL-35) in eumycetoma infection pathogenesis.
od: Amir Abushouk, et al.
Izdano: (2019-04-01)

The multifaceted role of IL-12 in cancer
od: Um e Habiba, et al.
Izdano: (2022-10-01)

Disseminated Mycobacterium simiae Infection in a Patient with Complete IL-12p40 Deficiency
od: Seyed Alireza Mahdaviani, et al.
Izdano: (2021-06-01)

Impact of Chronic Rhinosinusitis with Nasal Polyposis on IL-12 and IL-8
od: Jonatas do Amaral, et al.
Izdano: (2023-01-01)

IL-12p40/IL-23p40 Blockade With Ustekinumab Decreases the Synovial Inflammatory Infiltrate Through Modulation of Multiple Signaling Pathways Including MAPK-ERK and Wnt
od: Renée H. Fiechter, et al.
Izdano: (2021-03-01)

The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients
od: Abrar Kareem Dhari, et al.
Izdano: (2024-10-01)

Whole Tumor Cell Vaccine Adjuvants: Comparing IL-12 to IL-2 and IL-15
od: Abdolkarim Sheikhi, et al.
Izdano: (2016-09-01)

IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro.
od: Horwood, N, et al.
Izdano: (2001)

Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis
od: A. Khoshdel, et al.

IL-12p40 is essential but not sufficient for Francisella tularensis LVS clearance in chronically infected mice.
od: Lara R Mittereder, et al.
Izdano: (2023-01-01)

Evaluation of serum level of IL-12 in patients with
od: Mohammad Kazemi Arababadi1, et al.
Izdano: (2009-01-01)