Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly.
IL-12p40 partners with the p35 and p19 polypeptides to generate the heterodimeric cytokines IL-12 and IL-23, respectively. These cytokines play critical and distinct roles in host defense. The assembly of these heterodimers is thought to take place within the cell, resulting in the secretion of full...
Автори: | Abdi, K, Singh, N, Spooner, E, Kessler, B, Radaev, S, Lantz, L, Xiao, T, Matzinger, P, Sun, P, Ploegh, H |
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Формат: | Journal article |
Мова: | English |
Опубліковано: |
American Association of Immunologists
2014
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