Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival

<p><strong>Background:</strong> Glioblastoma is the most common and aggressive primary brain tumor with extremely poor prognosis, highlighting an urgent need for developing novel treatment options. Identifying epigenetic vulnerabilities of cancer cells can provide excellen...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Ozyerli-Goknar, E, Kala, EY, Aksu, AC, Bulut, I, Cingöz, A, Nizamuddin, S, Biniossek, M, Seker-Polat, F, Morova, T, Aztekin, C, Kung, SHY, Syed, H, Tuncbag, N, Gönen, M, Philpott, M, Cribbs, AP, Acilan, C, Lack, NA, Onder, TT, Timmers, HTM, Bagci-Onder, T
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	BioMed Central 2023

Antzeko izenburuak

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
nork: Ezgi Ozyerli-Goknar, et al.
Argitaratua: (2023-11-01)

EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities
nork: Yedier-Bayram, O, et al.
Argitaratua: (2022)

The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma
nork: Ozyerli-Goknar, E, et al.
Argitaratua: (2019)

Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer
nork: Saraç, H, et al.
Argitaratua: (2019)

Drug Repositioning Screen on a New Primary Cell Line Identifies Potent Therapeutics for Glioblastoma
nork: Filiz Senbabaoglu, et al.
Argitaratua: (2020-12-01)

EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities
nork: Ozlem Yedier-Bayram, et al.
Argitaratua: (2022-08-01)

Homeotic shift at the dawn of the turtle evolution
nork: Tomasz Szczygielski
Argitaratua: (2017-01-01)

Homeotic Genes: Clustering, Modularity, and Diversity
nork: Nikhil Hajirnis, et al.
Argitaratua: (2021-08-01)

Identification of selective SWI/SNF dependencies in enzalutamide-resistant prostate cancer
nork: Gokbayrak, B, et al.
Argitaratua: (2025)

Floral Homeotic Factors: A Question of Specificity
nork: Kevin Goslin, et al.
Argitaratua: (2023-03-01)

Multi-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular pathogenicity
nork: Koen M. A. Dreijerink, et al.
Argitaratua: (2022-08-01)

Homeotic transformations and number changes in the vertebral column of Triturus newts
nork: Maja Slijepčević, et al.
Argitaratua: (2015-11-01)

Homeotic compartment curvature and tension control spatiotemporal folding dynamics
nork: Aurélien Villedieu, et al.
Argitaratua: (2023-02-01)

Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression
nork: Lingjie Li, et al.
Argitaratua: (2013-10-01)

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming
nork: Ebrahimi, A, et al.
Argitaratua: (2019)

Functional evolution of cis-regulatory modules at a homeotic gene in Drosophila.
nork: Margaret C W Ho, et al.
Argitaratua: (2009-11-01)

Homeotic functions of the Teashirt transcription factor during adult Drosophila development
nork: Wei Wang, et al.
Argitaratua: (2012-10-01)

Breaking evolutionary and pleiotropic constraints in mammals: On sloths, manatees and homeotic mutations
nork: Varela-Lasheras Irma, et al.
Argitaratua: (2011-05-01)

Correction to: Breaking evolutionary and pleiotropic constraints in mammals: on sloths, manatees and homeotic mutations
nork: Irma Varela-Lasheras, et al.
Argitaratua: (2021-11-01)

Developmental robustness by obligate interaction of class B floral homeotic genes and proteins.
nork: Thorsten Lenser, et al.
Argitaratua: (2009-01-01)

Expression Pattern of a Homeotic Gene, HOXA5, in Normal Breast and in Breast Tumors
nork: Gregory S. Henderson, et al.
Argitaratua: (2006-01-01)

Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton.
nork: Esther Tijchon, et al.
Argitaratua: (2015-01-01)

Deregulated FGF and homeotic gene expression underlies cerebellar vermis hypoplasia in CHARGE syndrome
nork: Tian Yu, et al.
Argitaratua: (2013-12-01)

Homeotic evolution in the mammalia: diversification of therian axial seriation and the morphogenetic basis of human origins.
nork: Aaron G Filler
Argitaratua: (2007-10-01)

Exploiting epigenetic targets to overcome taxane resistance in prostate cancer
nork: Buse Cevatemre, et al.
Argitaratua: (2024-02-01)

Arabidopsis TCP4 transcription factor inhibits high temperature-induced homeotic conversion of ovules
nork: Jingqiu Lan, et al.
Argitaratua: (2023-09-01)

Integrated Epigenome, Exome, and Transcriptome Analyses Reveal Molecular Subtypes and Homeotic Transformation in Uterine Fibroids
nork: Jitu Wilson George, et al.
Argitaratua: (2019-12-01)

Positive selection and ancient duplications in the evolution of class B floral homeotic genes of orchids and grasses
nork: Koch Marcus A, et al.
Argitaratua: (2009-04-01)

Phenotypic characterization and genetic variability of Muthu Mullai mutants ofJasminum auriculatum for induction of homeotic mutants
nork: S P MIRUNALINI, et al.
Argitaratua: (2024-07-01)

Identification of selective SWI/SNF dependencies in enzalutamide-resistant prostate cancer
nork: Bengul Gokbayrak, et al.
Argitaratua: (2025-02-01)

Image of the Absent
nork: Ayellet Ben Ner
Argitaratua: (2015-10-01)

The Absent One
nork: Stefano Muneroni
Argitaratua: (2016-07-01)

CRISPR/Cas9 mediated knockout of the abdominal-A homeotic gene in fall armyworm moth (Spodoptera frugiperda).
nork: Ke Wu, et al.
Argitaratua: (2018-01-01)

HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring
nork: Shifeng Xue, et al.
Argitaratua: (2022-06-01)

Interpeler l’absent.
nork: Marie-Laure Florea
Argitaratua: (2010-10-01)

Team 10 Absent
nork: Ana Esteban Maluenda
Argitaratua: (2019-12-01)

Le peuple absent
nork: Nejma Kermele
Argitaratua: (2017-12-01)

Absent Value and Postmodernism
nork: Brian Crews
Argitaratua: (1999-12-01)

The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs.
nork: Milne, T, et al.
Argitaratua: (1999)

Transcription factor TFIIEβ interacts with two exposed positions in helix 2 of the Antennapedia homeodomain to control homeotic function in Drosophila.
nork: Claudia Altamirano-Torres, et al.
Argitaratua: (2018-01-01)