Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival

<p><strong>Background:</strong> Glioblastoma is the most common and aggressive primary brain tumor with extremely poor prognosis, highlighting an urgent need for developing novel treatment options. Identifying epigenetic vulnerabilities of cancer cells can provide excellen...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Ozyerli-Goknar, E, Kala, EY, Aksu, AC, Bulut, I, Cingöz, A, Nizamuddin, S, Biniossek, M, Seker-Polat, F, Morova, T, Aztekin, C, Kung, SHY, Syed, H, Tuncbag, N, Gönen, M, Philpott, M, Cribbs, AP, Acilan, C, Lack, NA, Onder, TT, Timmers, HTM, Bagci-Onder, T
Natura:	Journal article
Lingua:	English
Pubblicazione:	BioMed Central 2023

Documenti analoghi

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
di: Ezgi Ozyerli-Goknar, et al.
Pubblicazione: (2023-11-01)

EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities
di: Yedier-Bayram, O, et al.
Pubblicazione: (2022)

The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma
di: Ozyerli-Goknar, E, et al.
Pubblicazione: (2019)

Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer
di: Saraç, H, et al.
Pubblicazione: (2019)

Drug Repositioning Screen on a New Primary Cell Line Identifies Potent Therapeutics for Glioblastoma
di: Filiz Senbabaoglu, et al.
Pubblicazione: (2020-12-01)

EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities
di: Ozlem Yedier-Bayram, et al.
Pubblicazione: (2022-08-01)

Homeotic shift at the dawn of the turtle evolution
di: Tomasz Szczygielski
Pubblicazione: (2017-01-01)

Homeotic Genes: Clustering, Modularity, and Diversity
di: Nikhil Hajirnis, et al.
Pubblicazione: (2021-08-01)

Identification of selective SWI/SNF dependencies in enzalutamide-resistant prostate cancer
di: Gokbayrak, B, et al.
Pubblicazione: (2025)

Floral Homeotic Factors: A Question of Specificity
di: Kevin Goslin, et al.
Pubblicazione: (2023-03-01)

Multi-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular pathogenicity
di: Koen M. A. Dreijerink, et al.
Pubblicazione: (2022-08-01)

Homeotic transformations and number changes in the vertebral column of Triturus newts
di: Maja Slijepčević, et al.
Pubblicazione: (2015-11-01)

Homeotic compartment curvature and tension control spatiotemporal folding dynamics
di: Aurélien Villedieu, et al.
Pubblicazione: (2023-02-01)

Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression
di: Lingjie Li, et al.
Pubblicazione: (2013-10-01)

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming
di: Ebrahimi, A, et al.
Pubblicazione: (2019)

Functional evolution of cis-regulatory modules at a homeotic gene in Drosophila.
di: Margaret C W Ho, et al.
Pubblicazione: (2009-11-01)

Homeotic functions of the Teashirt transcription factor during adult Drosophila development
di: Wei Wang, et al.
Pubblicazione: (2012-10-01)

Breaking evolutionary and pleiotropic constraints in mammals: On sloths, manatees and homeotic mutations
di: Varela-Lasheras Irma, et al.
Pubblicazione: (2011-05-01)

Correction to: Breaking evolutionary and pleiotropic constraints in mammals: on sloths, manatees and homeotic mutations
di: Irma Varela-Lasheras, et al.
Pubblicazione: (2021-11-01)

Developmental robustness by obligate interaction of class B floral homeotic genes and proteins.
di: Thorsten Lenser, et al.
Pubblicazione: (2009-01-01)

Expression Pattern of a Homeotic Gene, HOXA5, in Normal Breast and in Breast Tumors
di: Gregory S. Henderson, et al.
Pubblicazione: (2006-01-01)

Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton.
di: Esther Tijchon, et al.
Pubblicazione: (2015-01-01)

Deregulated FGF and homeotic gene expression underlies cerebellar vermis hypoplasia in CHARGE syndrome
di: Tian Yu, et al.
Pubblicazione: (2013-12-01)

Homeotic evolution in the mammalia: diversification of therian axial seriation and the morphogenetic basis of human origins.
di: Aaron G Filler
Pubblicazione: (2007-10-01)

Exploiting epigenetic targets to overcome taxane resistance in prostate cancer
di: Buse Cevatemre, et al.
Pubblicazione: (2024-02-01)

Arabidopsis TCP4 transcription factor inhibits high temperature-induced homeotic conversion of ovules
di: Jingqiu Lan, et al.
Pubblicazione: (2023-09-01)

Integrated Epigenome, Exome, and Transcriptome Analyses Reveal Molecular Subtypes and Homeotic Transformation in Uterine Fibroids
di: Jitu Wilson George, et al.
Pubblicazione: (2019-12-01)

Positive selection and ancient duplications in the evolution of class B floral homeotic genes of orchids and grasses
di: Koch Marcus A, et al.
Pubblicazione: (2009-04-01)

Phenotypic characterization and genetic variability of Muthu Mullai mutants ofJasminum auriculatum for induction of homeotic mutants
di: S P MIRUNALINI, et al.
Pubblicazione: (2024-07-01)

Identification of selective SWI/SNF dependencies in enzalutamide-resistant prostate cancer
di: Bengul Gokbayrak, et al.
Pubblicazione: (2025-02-01)

Image of the Absent
di: Ayellet Ben Ner
Pubblicazione: (2015-10-01)

The Absent One
di: Stefano Muneroni
Pubblicazione: (2016-07-01)

CRISPR/Cas9 mediated knockout of the abdominal-A homeotic gene in fall armyworm moth (Spodoptera frugiperda).
di: Ke Wu, et al.
Pubblicazione: (2018-01-01)

HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring
di: Shifeng Xue, et al.
Pubblicazione: (2022-06-01)

Interpeler l’absent.
di: Marie-Laure Florea
Pubblicazione: (2010-10-01)

Team 10 Absent
di: Ana Esteban Maluenda
Pubblicazione: (2019-12-01)

Le peuple absent
di: Nejma Kermele
Pubblicazione: (2017-12-01)

Absent Value and Postmodernism
di: Brian Crews
Pubblicazione: (1999-12-01)

The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs.
di: Milne, T, et al.
Pubblicazione: (1999)

Transcription factor TFIIEβ interacts with two exposed positions in helix 2 of the Antennapedia homeodomain to control homeotic function in Drosophila.
di: Claudia Altamirano-Torres, et al.
Pubblicazione: (2018-01-01)