A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC).
BACKGROUND: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk. AIM: To assess the associations between height, BMI and serum concentrations of IGF-I and...
| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
2011
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| _version_ | 1826270100639973376 |
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| author | Crowe, F Key, T Allen, N Appleby, P Overvad, K Grønbæk, H Tjønneland, A Halkjær, J Dossus, L Boeing, H Kröger, J Trichopoulou, A Zylis, D Trichopoulos, D Boutron-Ruault, M de Lauzon-Guillain, B Clavel-Chapelon, F Palli, D Berrino, F Panico, S Tumino, R Sacerdote, C Bueno-de-Mesquita, H Gils, v Peeters, P |
| author_facet | Crowe, F Key, T Allen, N Appleby, P Overvad, K Grønbæk, H Tjønneland, A Halkjær, J Dossus, L Boeing, H Kröger, J Trichopoulou, A Zylis, D Trichopoulos, D Boutron-Ruault, M de Lauzon-Guillain, B Clavel-Chapelon, F Palli, D Berrino, F Panico, S Tumino, R Sacerdote, C Bueno-de-Mesquita, H Gils, v Peeters, P |
| author_sort | Crowe, F |
| collection | OXFORD |
| description | BACKGROUND: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk. AIM: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3. SUBJECTS AND METHODS: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC). RESULTS: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: - 0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m² had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all < 0.001). CONCLUSION: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers. |
| first_indexed | 2024-03-06T21:35:34Z |
| format | Journal article |
| id | oxford-uuid:4624229f-7109-4a46-81b2-e488ba1432ec |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:35:34Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:4624229f-7109-4a46-81b2-e488ba1432ec2022-03-26T15:12:02ZA cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4624229f-7109-4a46-81b2-e488ba1432ecEnglishSymplectic Elements at Oxford2011Crowe, FKey, TAllen, NAppleby, POvervad, KGrønbæk, HTjønneland, AHalkjær, JDossus, LBoeing, HKröger, JTrichopoulou, AZylis, DTrichopoulos, DBoutron-Ruault, Mde Lauzon-Guillain, BClavel-Chapelon, FPalli, DBerrino, FPanico, STumino, RSacerdote, CBueno-de-Mesquita, HGils, vPeeters, PBACKGROUND: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk. AIM: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3. SUBJECTS AND METHODS: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC). RESULTS: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: - 0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m² had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all < 0.001). CONCLUSION: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers. |
| spellingShingle | Crowe, F Key, T Allen, N Appleby, P Overvad, K Grønbæk, H Tjønneland, A Halkjær, J Dossus, L Boeing, H Kröger, J Trichopoulou, A Zylis, D Trichopoulos, D Boutron-Ruault, M de Lauzon-Guillain, B Clavel-Chapelon, F Palli, D Berrino, F Panico, S Tumino, R Sacerdote, C Bueno-de-Mesquita, H Gils, v Peeters, P A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title | A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_full | A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_fullStr | A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_full_unstemmed | A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_short | A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_sort | cross sectional analysis of the associations between adult height bmi and serum concentrations of igf i and igfbp 1 2 and 3 in the european prospective investigation into cancer and nutrition epic |
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