Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection.
Certain human leukocyte antigens, by presenting conserved immunogenic epitopes for T cell recognition, may, in part, account for the observed differences in human immunodeficiency virus type 1 (HIV-1) susceptibility. To determine whether HLA polymorphism influences HIV-1 susceptibility, a longitudin...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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| _version_ | 1797065971705315328 |
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| author | MacDonald, K Fowke, K Kimani, J Dunand, V Nagelkerke, N Ball, T Oyugi, J Njagi, E Gaur, L Brunham, R Wade, J Luscher, M Krausa, P Rowland-Jones, S Ngugi, E Bwayo, J Plummer, F |
| author_facet | MacDonald, K Fowke, K Kimani, J Dunand, V Nagelkerke, N Ball, T Oyugi, J Njagi, E Gaur, L Brunham, R Wade, J Luscher, M Krausa, P Rowland-Jones, S Ngugi, E Bwayo, J Plummer, F |
| author_sort | MacDonald, K |
| collection | OXFORD |
| description | Certain human leukocyte antigens, by presenting conserved immunogenic epitopes for T cell recognition, may, in part, account for the observed differences in human immunodeficiency virus type 1 (HIV-1) susceptibility. To determine whether HLA polymorphism influences HIV-1 susceptibility, a longitudinal cohort of highly HIV-1-exposed female sex workers based in Nairobi, Kenya, was prospectively analyzed. Decreased HIV-1 infection risk was strongly associated with possession of a cluster of closely related HLA alleles (A2/6802 supertype; incidence rate ratio [IRR], 0.45; 95% confidence interval [CI], 0.27-0.72; P=.0003). The alleles in this supertype are known in some cases to present the same peptide epitopes for T cell recognition. In addition, resistance to HIV-1 infection was independently associated with HLA DRB1*01 (IRR, 0.22; 95% CI, 0.06-0.60; P=.0003), which suggests that anti-HIV-1 class II restricted CD4 effector mechanisms may play an important role in protecting against viral challenge. These data provide further evidence that resistance to HIV-1 infection in this cohort of sex workers is immunologically mediated. |
| first_indexed | 2024-03-06T21:35:51Z |
| format | Journal article |
| id | oxford-uuid:463b6a9d-9edd-491a-b892-013c8aeaf1d3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:35:51Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:463b6a9d-9edd-491a-b892-013c8aeaf1d32022-03-26T15:12:31ZInfluence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:463b6a9d-9edd-491a-b892-013c8aeaf1d3EnglishSymplectic Elements at Oxford2000MacDonald, KFowke, KKimani, JDunand, VNagelkerke, NBall, TOyugi, JNjagi, EGaur, LBrunham, RWade, JLuscher, MKrausa, PRowland-Jones, SNgugi, EBwayo, JPlummer, FCertain human leukocyte antigens, by presenting conserved immunogenic epitopes for T cell recognition, may, in part, account for the observed differences in human immunodeficiency virus type 1 (HIV-1) susceptibility. To determine whether HLA polymorphism influences HIV-1 susceptibility, a longitudinal cohort of highly HIV-1-exposed female sex workers based in Nairobi, Kenya, was prospectively analyzed. Decreased HIV-1 infection risk was strongly associated with possession of a cluster of closely related HLA alleles (A2/6802 supertype; incidence rate ratio [IRR], 0.45; 95% confidence interval [CI], 0.27-0.72; P=.0003). The alleles in this supertype are known in some cases to present the same peptide epitopes for T cell recognition. In addition, resistance to HIV-1 infection was independently associated with HLA DRB1*01 (IRR, 0.22; 95% CI, 0.06-0.60; P=.0003), which suggests that anti-HIV-1 class II restricted CD4 effector mechanisms may play an important role in protecting against viral challenge. These data provide further evidence that resistance to HIV-1 infection in this cohort of sex workers is immunologically mediated. |
| spellingShingle | MacDonald, K Fowke, K Kimani, J Dunand, V Nagelkerke, N Ball, T Oyugi, J Njagi, E Gaur, L Brunham, R Wade, J Luscher, M Krausa, P Rowland-Jones, S Ngugi, E Bwayo, J Plummer, F Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection. |
| title | Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection. |
| title_full | Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection. |
| title_fullStr | Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection. |
| title_full_unstemmed | Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection. |
| title_short | Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection. |
| title_sort | influence of hla supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection |
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