HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo.

HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo.

In tumor cells with mutations in epidermal growth factor receptor (SQ20B), H-Ras (T24), or K-Ras (MIAPACA2 and A549), the inhibition of Akt phosphorylation increases radiation sensitivity in clonogenic assays, suggesting that Akt is a potential molecular target when combined with therapeutic radiati...

Bibliografski detalji
Glavni autori:	Gupta, A, Cerniglia, G, Mick, R, Mckenna, W, Muschel, R
Format:	Journal article
Jezik:	English
Izdano:	2005

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