The contribution of L-arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: A review of rtPA neurotoxicity

The contribution of L-arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: A review of rtPA neurotoxicity

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Alteplase is the only drug licensed for acute ischemic stroke, and in this formulation, the thrombolytic agent recombinant tissue plasminogen activator (rtPA) is stabilized in a solution of L-arginine. Improved functional outcomes after alteplase administration have been shown in clinical trials, al...

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Bibliographic Details
Main Authors:	Harston, G, Sutherland, B, Kennedy, J, Buchan, A
Format:	Journal article
Language:	English
Published:	2010

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