Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1 mutant myelodysplastic syndromes

Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1 mutant myelodysplastic syndromes

The splicing factor SF3B1 is the most frequently mutated gene in the myelodysplastic syndromes (MDS), and is strongly associated with the presence of ring sideroblasts (RS). We have performed a systematic analysis of cryptic splicing abnormalities from RNA-sequencing data on hematopoietic stem cells...

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Dades bibliogràfiques
Autors principals: Dolatshad, H, Repapi, E, Steeples, V, Roy, S, Scifo, L, Armstrong, R, Shaw, J, Yip, B, Taylor, S, Boultwood, J, Liberante, F, Llorian, M, Killick, S, Kusec, R, Mills, K, Savage, K, Smith, C, Pellagatti, A
Format: Journal article
Publicat: Nature Publishing Group 2016

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