Traumatic brain injury impairs small-world topology.
OBJECTIVE: We test the hypothesis that brain networks associated with cognitive function shift away from a "small-world" organization following traumatic brain injury (TBI). METHODS: We investigated 20 TBI patients and 21 age-matched controls. Resting-state functional MRI was used to study...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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| _version_ | 1797066069469298688 |
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| author | Pandit, A Expert, P Lambiotte, R Bonnelle, V Leech, R Turkheimer, F Sharp, D |
| author_facet | Pandit, A Expert, P Lambiotte, R Bonnelle, V Leech, R Turkheimer, F Sharp, D |
| author_sort | Pandit, A |
| collection | OXFORD |
| description | OBJECTIVE: We test the hypothesis that brain networks associated with cognitive function shift away from a "small-world" organization following traumatic brain injury (TBI). METHODS: We investigated 20 TBI patients and 21 age-matched controls. Resting-state functional MRI was used to study functional connectivity. Graph theoretical analysis was then applied to partial correlation matrices derived from these data. The presence of white matter damage was quantified using diffusion tensor imaging. RESULTS: Patients showed characteristic cognitive impairments as well as evidence of damage to white matter tracts. Compared to controls, the graph analysis showed reduced overall connectivity, longer average path lengths, and reduced network efficiency. A particular impact of TBI is seen on a major network hub, the posterior cingulate cortex. Taken together, these results confirm that a network critical to cognitive function shows a shift away from small-world characteristics. CONCLUSIONS: We provide evidence that key brain networks involved in supporting cognitive function become less small-world in their organization after TBI. This is likely to be the result of diffuse white matter damage, and may be an important factor in producing cognitive impairment after TBI. |
| first_indexed | 2024-03-06T21:37:07Z |
| format | Journal article |
| id | oxford-uuid:46a28784-7088-44f5-a6c3-b91d297b5b0e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:37:07Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:46a28784-7088-44f5-a6c3-b91d297b5b0e2022-03-26T15:14:57ZTraumatic brain injury impairs small-world topology.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:46a28784-7088-44f5-a6c3-b91d297b5b0eEnglishSymplectic Elements at Oxford2013Pandit, AExpert, PLambiotte, RBonnelle, VLeech, RTurkheimer, FSharp, DOBJECTIVE: We test the hypothesis that brain networks associated with cognitive function shift away from a "small-world" organization following traumatic brain injury (TBI). METHODS: We investigated 20 TBI patients and 21 age-matched controls. Resting-state functional MRI was used to study functional connectivity. Graph theoretical analysis was then applied to partial correlation matrices derived from these data. The presence of white matter damage was quantified using diffusion tensor imaging. RESULTS: Patients showed characteristic cognitive impairments as well as evidence of damage to white matter tracts. Compared to controls, the graph analysis showed reduced overall connectivity, longer average path lengths, and reduced network efficiency. A particular impact of TBI is seen on a major network hub, the posterior cingulate cortex. Taken together, these results confirm that a network critical to cognitive function shows a shift away from small-world characteristics. CONCLUSIONS: We provide evidence that key brain networks involved in supporting cognitive function become less small-world in their organization after TBI. This is likely to be the result of diffuse white matter damage, and may be an important factor in producing cognitive impairment after TBI. |
| spellingShingle | Pandit, A Expert, P Lambiotte, R Bonnelle, V Leech, R Turkheimer, F Sharp, D Traumatic brain injury impairs small-world topology. |
| title | Traumatic brain injury impairs small-world topology. |
| title_full | Traumatic brain injury impairs small-world topology. |
| title_fullStr | Traumatic brain injury impairs small-world topology. |
| title_full_unstemmed | Traumatic brain injury impairs small-world topology. |
| title_short | Traumatic brain injury impairs small-world topology. |
| title_sort | traumatic brain injury impairs small world topology |
| work_keys_str_mv | AT pandita traumaticbraininjuryimpairssmallworldtopology AT expertp traumaticbraininjuryimpairssmallworldtopology AT lambiotter traumaticbraininjuryimpairssmallworldtopology AT bonnellev traumaticbraininjuryimpairssmallworldtopology AT leechr traumaticbraininjuryimpairssmallworldtopology AT turkheimerf traumaticbraininjuryimpairssmallworldtopology AT sharpd traumaticbraininjuryimpairssmallworldtopology |