Modelling Cell Migration and Adhesion During Development
Cell-cell adhesion is essential for biological development: cells migrate to their target sites, where cell-cell adhesion enables them to aggregate and form tissues. Here, we extend analysis of the model of cell migration proposed by Anguige and Schmeiser (J. Math. Biol. 58(3):395-427, 2009) that in...
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1797066081667383296 |
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| author | Thompson, R Yates, C Baker, R |
| author_facet | Thompson, R Yates, C Baker, R |
| author_sort | Thompson, R |
| collection | OXFORD |
| description | Cell-cell adhesion is essential for biological development: cells migrate to their target sites, where cell-cell adhesion enables them to aggregate and form tissues. Here, we extend analysis of the model of cell migration proposed by Anguige and Schmeiser (J. Math. Biol. 58(3):395-427, 2009) that incorporates both cell-cell adhesion and volume filling. The stochastic space-jump model is compared to two deterministic counterparts (a system of stochastic mean equations and a non-linear partial differential equation), and it is shown that the results of the deterministic systems are, in general, qualitatively similar to the mean behaviour of multiple stochastic simulations. However, individual stochastic simulations can give rise to behaviour that varies significantly from that of the mean. In particular, individual simulations might admit cell clustering when the mean behaviour does not. We also investigate the potential of this model to display behaviour predicted by the differential adhesion hypothesis by incorporating a second cell species, and present a novel approach for implementing models of cell migration on a growing domain. © 2012 Society for Mathematical Biology. |
| first_indexed | 2024-03-06T21:37:16Z |
| format | Journal article |
| id | oxford-uuid:46b033f7-fcf6-467b-a210-30c65b83b085 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:37:16Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:46b033f7-fcf6-467b-a210-30c65b83b0852022-03-26T15:15:13ZModelling Cell Migration and Adhesion During DevelopmentJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:46b033f7-fcf6-467b-a210-30c65b83b085EnglishSymplectic Elements at Oxford2012Thompson, RYates, CBaker, RCell-cell adhesion is essential for biological development: cells migrate to their target sites, where cell-cell adhesion enables them to aggregate and form tissues. Here, we extend analysis of the model of cell migration proposed by Anguige and Schmeiser (J. Math. Biol. 58(3):395-427, 2009) that incorporates both cell-cell adhesion and volume filling. The stochastic space-jump model is compared to two deterministic counterparts (a system of stochastic mean equations and a non-linear partial differential equation), and it is shown that the results of the deterministic systems are, in general, qualitatively similar to the mean behaviour of multiple stochastic simulations. However, individual stochastic simulations can give rise to behaviour that varies significantly from that of the mean. In particular, individual simulations might admit cell clustering when the mean behaviour does not. We also investigate the potential of this model to display behaviour predicted by the differential adhesion hypothesis by incorporating a second cell species, and present a novel approach for implementing models of cell migration on a growing domain. © 2012 Society for Mathematical Biology. |
| spellingShingle | Thompson, R Yates, C Baker, R Modelling Cell Migration and Adhesion During Development |
| title | Modelling Cell Migration and Adhesion During Development |
| title_full | Modelling Cell Migration and Adhesion During Development |
| title_fullStr | Modelling Cell Migration and Adhesion During Development |
| title_full_unstemmed | Modelling Cell Migration and Adhesion During Development |
| title_short | Modelling Cell Migration and Adhesion During Development |
| title_sort | modelling cell migration and adhesion during development |
| work_keys_str_mv | AT thompsonr modellingcellmigrationandadhesionduringdevelopment AT yatesc modellingcellmigrationandadhesionduringdevelopment AT bakerr modellingcellmigrationandadhesionduringdevelopment |