Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations

Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations

Forward genetics screens with N-ethyl-N-nitrosourea (ENU) provide a powerful way to illuminate gene function and generate mouse models of human disease; however, the identification of causative mutations remains a limiting step. Current strategies depend on conventional mapping, so the propagation o...

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Bibliographic Details
Main Authors: Bull, K, Rimmer, A, Siggs, O, Miosge, L, Roots, C, Enders, A, Bertram, E, Crockford, T, Whittle, B, Potter, P, Simon, M, Mallon, A, Brown, S, Beutler, B, Goodnow, C, Lunter, G, Cornall, R
Format: Journal article
Language:English
Published: Public Library of Science 2013

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