11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects.

11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects.

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) interconverts the inactive glucocorticoid cortisone and its active form cortisol. It is widely expressed and, although bidirectional, in vivo it functions predominantly as an oxoreductase, generating active glucocorticoid. This allows glucocorticoid...

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Bibliographic Details
Main Authors:	Gathercole, L, Lavery, G, Morgan, SA, Cooper, MS, Sinclair, A, Tomlinson, J, Stewart, P
Format:	Journal article
Language:	English
Published:	2013

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