A 41-year-old woman with acute weakness and encephalopathy associated with MOG antibodies.
Antibodies to native glycosylated myelin oligodendrocyte glycoprotein (MOG), measured by cell-based assays, have been reported in adults with acute disseminated encephalomyelitis (ADEM) and in children with demyelinating diseases, including multiple sclerosis (MS) and ADEM. More recently, antibodies...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Wolters Kluwer Health
2015
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| _version_ | 1797066114014904320 |
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| author | Morris, K Waters, P Woodhall, M Kuker, W Vincent, A Leite, M Sen, A |
| author_facet | Morris, K Waters, P Woodhall, M Kuker, W Vincent, A Leite, M Sen, A |
| author_sort | Morris, K |
| collection | OXFORD |
| description | Antibodies to native glycosylated myelin oligodendrocyte glycoprotein (MOG), measured by cell-based assays, have been reported in adults with acute disseminated encephalomyelitis (ADEM) and in children with demyelinating diseases, including multiple sclerosis (MS) and ADEM. More recently, antibodies to both truncated1 and full-length2 MOG have been identified in a few adults with aquaporin-4 (AQP4) antibody–negative neuromyelitis optica spectrum disorder (NMOSD). We report a patient with a rapidly worsening longitudinally extensive transverse myelitis (LETM) whose serum antibodies were subsequently found to bind the full-length version of MOG. Aggressive and early immunomodulation correlated closely with reduction in MOG titer and clinical improvement. |
| first_indexed | 2024-03-06T21:37:45Z |
| format | Journal article |
| id | oxford-uuid:46d9aba8-96c5-4958-9cc9-40004ffc3dd8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:37:45Z |
| publishDate | 2015 |
| publisher | Wolters Kluwer Health |
| record_format | dspace |
| spelling | oxford-uuid:46d9aba8-96c5-4958-9cc9-40004ffc3dd82022-03-26T15:16:18ZA 41-year-old woman with acute weakness and encephalopathy associated with MOG antibodies.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:46d9aba8-96c5-4958-9cc9-40004ffc3dd8EnglishSymplectic Elements at OxfordWolters Kluwer Health2015Morris, KWaters, PWoodhall, MKuker, WVincent, ALeite, MSen, AAntibodies to native glycosylated myelin oligodendrocyte glycoprotein (MOG), measured by cell-based assays, have been reported in adults with acute disseminated encephalomyelitis (ADEM) and in children with demyelinating diseases, including multiple sclerosis (MS) and ADEM. More recently, antibodies to both truncated1 and full-length2 MOG have been identified in a few adults with aquaporin-4 (AQP4) antibody–negative neuromyelitis optica spectrum disorder (NMOSD). We report a patient with a rapidly worsening longitudinally extensive transverse myelitis (LETM) whose serum antibodies were subsequently found to bind the full-length version of MOG. Aggressive and early immunomodulation correlated closely with reduction in MOG titer and clinical improvement. |
| spellingShingle | Morris, K Waters, P Woodhall, M Kuker, W Vincent, A Leite, M Sen, A A 41-year-old woman with acute weakness and encephalopathy associated with MOG antibodies. |
| title | A 41-year-old woman with acute weakness and encephalopathy associated with MOG antibodies. |
| title_full | A 41-year-old woman with acute weakness and encephalopathy associated with MOG antibodies. |
| title_fullStr | A 41-year-old woman with acute weakness and encephalopathy associated with MOG antibodies. |
| title_full_unstemmed | A 41-year-old woman with acute weakness and encephalopathy associated with MOG antibodies. |
| title_short | A 41-year-old woman with acute weakness and encephalopathy associated with MOG antibodies. |
| title_sort | 41 year old woman with acute weakness and encephalopathy associated with mog antibodies |
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