Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2.

Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2.

We have identified an HLA-A2-restricted CD8(+) T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but un...

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Bibliographic Details
Main Authors: Lautscham, G, Haigh, T, Mayrhofer, S, Taylor, G, Croom-Carter, D, Leese, A, Gadola, S, Cerundolo, V, Rickinson, A, Blake, N
Format: Journal article
Language:English
Published: 2003

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