Morphologic changes and molecular regulation of angiogenesis in pituitary adenomas.
Angiogenesis, the process of development of a new vasculature, plays a crucial role in tumour growth. In the pituitary, unlike other tissues, vascularization is lower in adenomas compared to the normal gland. Despite this finding, a relationship between increased vascularity and some aspects of tumo...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1797066138947944448 |
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| author | de la Torre, N Wass, J Turner, H |
| author_facet | de la Torre, N Wass, J Turner, H |
| author_sort | de la Torre, N |
| collection | OXFORD |
| description | Angiogenesis, the process of development of a new vasculature, plays a crucial role in tumour growth. In the pituitary, unlike other tissues, vascularization is lower in adenomas compared to the normal gland. Despite this finding, a relationship between increased vascularity and some aspects of tumour behaviour such as size, invasiveness, surgical outcome and malignancy, has been demonstrated. The process of angiogenesis is the result of a balance of stimulating and inhibiting factors. It is likely that an interaction between gene expression (such as pituitary tumour transforming gene), hormonal stimuli including oestrogens, corticosteroids, dopamine, 16-kDa fragments of prolactin and growth hormone, somatostatin analogues, and pro- and anti-angiogenic growth factors (e.g. vascular endothelial growth factor and fibroblast growth factor), determine the final angiogenic phenotype of pituitary tumours, and thus subsequent tumour behaviour. |
| first_indexed | 2024-03-06T21:38:07Z |
| format | Journal article |
| id | oxford-uuid:46f7fb5d-425c-4b7e-b88c-88ea46c6f6e6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:38:07Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:46f7fb5d-425c-4b7e-b88c-88ea46c6f6e62022-03-26T15:17:12ZMorphologic changes and molecular regulation of angiogenesis in pituitary adenomas.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:46f7fb5d-425c-4b7e-b88c-88ea46c6f6e6EnglishSymplectic Elements at Oxford2004de la Torre, NWass, JTurner, HAngiogenesis, the process of development of a new vasculature, plays a crucial role in tumour growth. In the pituitary, unlike other tissues, vascularization is lower in adenomas compared to the normal gland. Despite this finding, a relationship between increased vascularity and some aspects of tumour behaviour such as size, invasiveness, surgical outcome and malignancy, has been demonstrated. The process of angiogenesis is the result of a balance of stimulating and inhibiting factors. It is likely that an interaction between gene expression (such as pituitary tumour transforming gene), hormonal stimuli including oestrogens, corticosteroids, dopamine, 16-kDa fragments of prolactin and growth hormone, somatostatin analogues, and pro- and anti-angiogenic growth factors (e.g. vascular endothelial growth factor and fibroblast growth factor), determine the final angiogenic phenotype of pituitary tumours, and thus subsequent tumour behaviour. |
| spellingShingle | de la Torre, N Wass, J Turner, H Morphologic changes and molecular regulation of angiogenesis in pituitary adenomas. |
| title | Morphologic changes and molecular regulation of angiogenesis in pituitary adenomas. |
| title_full | Morphologic changes and molecular regulation of angiogenesis in pituitary adenomas. |
| title_fullStr | Morphologic changes and molecular regulation of angiogenesis in pituitary adenomas. |
| title_full_unstemmed | Morphologic changes and molecular regulation of angiogenesis in pituitary adenomas. |
| title_short | Morphologic changes and molecular regulation of angiogenesis in pituitary adenomas. |
| title_sort | morphologic changes and molecular regulation of angiogenesis in pituitary adenomas |
| work_keys_str_mv | AT delatorren morphologicchangesandmolecularregulationofangiogenesisinpituitaryadenomas AT wassj morphologicchangesandmolecularregulationofangiogenesisinpituitaryadenomas AT turnerh morphologicchangesandmolecularregulationofangiogenesisinpituitaryadenomas |