A large deletion in the human alpha-globin cluster caused by a replication error is associated with an unexpectedly mild phenotype.
We have characterized a newly identified 16.6 kb deletion which removes a significant proportion of the human alpha-globin cluster including the psizeta1, alpha(D), psialpha1 and alpha2-globin genes but leaves the duplicated alpha1 gene intact. This complicated rearrangement results from a combinati...
Κύριοι συγγραφείς: | Rugless, M, Fisher, C, Old, J, Sloane-Stanley, J, Ayyub, H, Higgs, D, Garrick, D |
---|---|
Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
2008
|
Παρόμοια τεκμήρια
Παρόμοια τεκμήρια
-
A 16.5 kb deletion in the alpha globin cluster associated with an extremely mild phenotype
ανά: Rugless, M, κ.ά.
Έκδοση: (2007) -
Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype.
ανά: Anguita, E, κ.ά.
Έκδοση: (2002) -
Deletion of the mouse alpha globin regulatory element (HS-26) has an unexpectedly mild phenotype.
ανά: Anguita, E, κ.ά.
Έκδοση: (2003) -
The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells.
ανά: Garrick, D, κ.ά.
Έκδοση: (2008) -
A novel deletion causing alpha thalassemia clarifies the importance of the major human alpha globin regulatory element.
ανά: Viprakasit, V, κ.ά.
Έκδοση: (2006)