Equilibration in bicyclic pyroglutamates by ring opening-reclosure

Enantiopure bicyclic tetramates, readily obtained by Dieckmann ring closure on oxazolidine-derived templates, can be further converted to hydroxypyroglutamates by kinetically controlled nucleophilic additions, and some of these products are capable of equilibration via a facile retro-aldol/aldol rec...

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Opis bibliograficzny
Główni autorzy: Moloney, M, Yaqoob, M
Format: Journal article
Język:English
Wydane: 2008
Opis
Streszczenie:Enantiopure bicyclic tetramates, readily obtained by Dieckmann ring closure on oxazolidine-derived templates, can be further converted to hydroxypyroglutamates by kinetically controlled nucleophilic additions, and some of these products are capable of equilibration via a facile retro-aldol/aldol reclosure. © 2008 Elsevier Ltd. All rights reserved.