Renewed focus on the developing human neocortex.
Many specifically human psychiatric and neurological conditions have developmental origins. Rodent models are extremely valuable for the investigation of brain development, but cannot provide insight into aspects that are specifically human. The human brain, and particularly the cerebral cortex, has...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1826270318234173440 |
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| author | Clowry, G Molnár, Z Rakic, P |
| author_facet | Clowry, G Molnár, Z Rakic, P |
| author_sort | Clowry, G |
| collection | OXFORD |
| description | Many specifically human psychiatric and neurological conditions have developmental origins. Rodent models are extremely valuable for the investigation of brain development, but cannot provide insight into aspects that are specifically human. The human brain, and particularly the cerebral cortex, has some unique genetic, molecular, cellular and anatomical features, and these need to be further explored. Cortical expansion in human is not just quantitative; there are some novel types of neurons and cytoarchitectonic areas identified by their gene expression, connectivity and functions that do not exist in rodents. Recent research into human brain development has revealed more elaborated neurogenetic compartments, radial and tangential migration, transient cell layers in the subplate, and a greater diversity of early-generated neurons, including predecessor neurons. Recently there has been a renaissance of the study of human brain development because of these unique differences, made possible by the availability of new techniques. This review gives a flavour of the recent studies stemming from this renewed focus on the developing human brain. |
| first_indexed | 2024-03-06T21:38:58Z |
| format | Journal article |
| id | oxford-uuid:473e65f4-f09e-4969-b91e-c08867a25998 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:38:58Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:473e65f4-f09e-4969-b91e-c08867a259982022-03-26T15:18:56ZRenewed focus on the developing human neocortex.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:473e65f4-f09e-4969-b91e-c08867a25998EnglishSymplectic Elements at Oxford2010Clowry, GMolnár, ZRakic, PMany specifically human psychiatric and neurological conditions have developmental origins. Rodent models are extremely valuable for the investigation of brain development, but cannot provide insight into aspects that are specifically human. The human brain, and particularly the cerebral cortex, has some unique genetic, molecular, cellular and anatomical features, and these need to be further explored. Cortical expansion in human is not just quantitative; there are some novel types of neurons and cytoarchitectonic areas identified by their gene expression, connectivity and functions that do not exist in rodents. Recent research into human brain development has revealed more elaborated neurogenetic compartments, radial and tangential migration, transient cell layers in the subplate, and a greater diversity of early-generated neurons, including predecessor neurons. Recently there has been a renaissance of the study of human brain development because of these unique differences, made possible by the availability of new techniques. This review gives a flavour of the recent studies stemming from this renewed focus on the developing human brain. |
| spellingShingle | Clowry, G Molnár, Z Rakic, P Renewed focus on the developing human neocortex. |
| title | Renewed focus on the developing human neocortex. |
| title_full | Renewed focus on the developing human neocortex. |
| title_fullStr | Renewed focus on the developing human neocortex. |
| title_full_unstemmed | Renewed focus on the developing human neocortex. |
| title_short | Renewed focus on the developing human neocortex. |
| title_sort | renewed focus on the developing human neocortex |
| work_keys_str_mv | AT clowryg renewedfocusonthedevelopinghumanneocortex AT molnarz renewedfocusonthedevelopinghumanneocortex AT rakicp renewedfocusonthedevelopinghumanneocortex |