Primaquine for prevention of malaria in travelers.
An expanding risk and range of endemic malaria threatens travelers. Primaquine is an old drug recently demonstrated to offer effective prophylaxis. Clinical trials conducted in Indonesia, Kenya, and Colombia showed that a primaquine base (30 mg per day) had protective efficacy against Plasmodium fal...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1797066247877165056 |
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| author | Baird, J Fryauff, D Hoffman, S |
| author_facet | Baird, J Fryauff, D Hoffman, S |
| author_sort | Baird, J |
| collection | OXFORD |
| description | An expanding risk and range of endemic malaria threatens travelers. Primaquine is an old drug recently demonstrated to offer effective prophylaxis. Clinical trials conducted in Indonesia, Kenya, and Colombia showed that a primaquine base (30 mg per day) had protective efficacy against Plasmodium falciparum and Plasmodium vivax of 85%-93%. Among 339 children (age, >8 years) and adults taking this regimen for 12-52 weeks, there was no greater risk of adverse symptomatic events among primaquine users than among recipients of placebo in double-blind studies. Among 151 subjects evaluated after 20 or 52 weeks of daily primaquine therapy, methemoglobinemia was found to be mild (<13%; typically <6%) and transient (duration, <2 weeks). We consider primaquine base (0.5 mg/kg per day consumed with food) to be safe, well-tolerated, and effective prophylaxis against malaria for nonpregnant persons and those with normal glucose-6-phosphate dehydrogenase levels. Primaquine's major advantage over most drugs for chemoprophylaxis is that it does not have to be taken before entering or beyond 3 days after leaving a malarious area. |
| first_indexed | 2024-03-06T21:39:44Z |
| format | Journal article |
| id | oxford-uuid:477f1cbe-805a-45c1-85a3-f0c0c1d502a1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:39:44Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:477f1cbe-805a-45c1-85a3-f0c0c1d502a12022-03-26T15:20:27ZPrimaquine for prevention of malaria in travelers.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:477f1cbe-805a-45c1-85a3-f0c0c1d502a1EnglishSymplectic Elements at Oxford2003Baird, JFryauff, DHoffman, SAn expanding risk and range of endemic malaria threatens travelers. Primaquine is an old drug recently demonstrated to offer effective prophylaxis. Clinical trials conducted in Indonesia, Kenya, and Colombia showed that a primaquine base (30 mg per day) had protective efficacy against Plasmodium falciparum and Plasmodium vivax of 85%-93%. Among 339 children (age, >8 years) and adults taking this regimen for 12-52 weeks, there was no greater risk of adverse symptomatic events among primaquine users than among recipients of placebo in double-blind studies. Among 151 subjects evaluated after 20 or 52 weeks of daily primaquine therapy, methemoglobinemia was found to be mild (<13%; typically <6%) and transient (duration, <2 weeks). We consider primaquine base (0.5 mg/kg per day consumed with food) to be safe, well-tolerated, and effective prophylaxis against malaria for nonpregnant persons and those with normal glucose-6-phosphate dehydrogenase levels. Primaquine's major advantage over most drugs for chemoprophylaxis is that it does not have to be taken before entering or beyond 3 days after leaving a malarious area. |
| spellingShingle | Baird, J Fryauff, D Hoffman, S Primaquine for prevention of malaria in travelers. |
| title | Primaquine for prevention of malaria in travelers. |
| title_full | Primaquine for prevention of malaria in travelers. |
| title_fullStr | Primaquine for prevention of malaria in travelers. |
| title_full_unstemmed | Primaquine for prevention of malaria in travelers. |
| title_short | Primaquine for prevention of malaria in travelers. |
| title_sort | primaquine for prevention of malaria in travelers |
| work_keys_str_mv | AT bairdj primaquineforpreventionofmalariaintravelers AT fryauffd primaquineforpreventionofmalariaintravelers AT hoffmans primaquineforpreventionofmalariaintravelers |