Studies on side chain interactions during the isopenicillin N synthase catalysed biosynthesis of penicillins

The role of the L-δ-(α-aminoadipoyl)-L-cysteinyl amide bond in isopenicillin N synthase catalysis is probed by the synthesis of two analogues of its tripeptide substrate L-δ-α-aminoadipoyl-L-cysteinyl-D-valine.

Manylion Llyfryddiaeth
Prif Awduron:	Cavelier, F, Russell, A, Schofield, C, Baldwin, J
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	1997

Eitemau Tebyg

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
gan: Roach, P, et al.
Cyhoeddwyd: (1997)

EXAFS STUDIES OF ISOPENICILLIN-N SYNTHASE
gan: Randall, C, et al.
Cyhoeddwyd: (1992)

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
gan: Baldwin, J, et al.
Cyhoeddwyd: (1991)

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
gan: Baldwin, J, et al.
Cyhoeddwyd: (1992)

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in ß-lactam biosynthesis
gan: Rabe, P, et al.
Cyhoeddwyd: (2018)

FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE
gan: Baldwin, J, et al.
Cyhoeddwyd: (1989)

GAMMA-LACTAM FORMATION FROM TRIPEPTIDES WITH ISOPENICILLIN-N SYNTHASE
gan: Baldwin, J, et al.
Cyhoeddwyd: (1988)

Molecular weight analysis of isopenicillin N synthase by electrospray mass spectrometry.
gan: Aplin, RT, et al.
Cyhoeddwyd: (1990)

Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans.
gan: Sami, M, et al.
Cyhoeddwyd: (1997)

Mechanistic studies on isopenicillin n synthase
gan: Abbott, S
Cyhoeddwyd: (1991)

Occurrence of Isopenicillin-N-Synthase Homologs in Bioluminescent Ctenophores and Implications for Coelenterazine Biosynthesis.
gan: Warren R Francis, et al.
Cyhoeddwyd: (2015-01-01)

Studies of isopenicillin N synthase enzymatic properties using a continuous spectrophotometric assay.
gan: Dubus, A, et al.
Cyhoeddwyd: (2000)

The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.
gan: Daruzzaman, A, et al.
Cyhoeddwyd: (2013)

Crystallization and preliminary X-ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans.
gan: Roach, P, et al.
Cyhoeddwyd: (1995)

SIDE-CHAIN SPECIFICITY IN THE ENZYMATIC-SYNTHESIS OF PENICILLINS
gan: Baldwin, J, et al.
Cyhoeddwyd: (1990)

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
gan: Roach, P, et al.
Cyhoeddwyd: (1995)

Modification of iron binding ligands in isopenicillin n synthase
gan: Sami, M, et al.
Cyhoeddwyd: (1998)

Crystallization and preliminary X-ray diffraction studies on a recombinant isopenicillin N synthase from Cephalosporium acremonium.
gan: Fujishima, Y, et al.
Cyhoeddwyd: (1994)

X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes.
gan: Randall, C, et al.
Cyhoeddwyd: (1993)

Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies.
gan: Roach, P, et al.
Cyhoeddwyd: (1996)

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.
gan: Ge, W, et al.
Cyhoeddwyd: (2010)

THE FATE OF VALINE-OXYGEN DURING PENICILLIN BIOSYNTHESIS
gan: Baldwin, J, et al.
Cyhoeddwyd: (1989)

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.
gan: Ge, W, et al.
Cyhoeddwyd: (2010)

Photoaffinity labelling of isopenicillin N synthetase.
gan: Baldwin, J, et al.
Cyhoeddwyd: (1990)

Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue.
gan: Ge, W, et al.
Cyhoeddwyd: (2009)

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.
gan: Long, A, et al.
Cyhoeddwyd: (2003)

THE ENZYMATIC RING EXPANSION OF PENICILLINS TO CEPHALOSPORINS - SIDE-CHAIN SPECIFICITY
gan: Baldwin, J, et al.
Cyhoeddwyd: (1987)

Proteins of the penicillin biosynthesis pathway.
gan: Schofield, C, et al.
Cyhoeddwyd: (1997)

Anaerobic crystallisation of an isopenicillin N synthase center dot Fe(II)center dot substrate complex demonstrated by X-ray studies
gan: Roach, P, et al.
Cyhoeddwyd: (1996)

Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles.
gan: Hamed, R, et al.
Cyhoeddwyd: (2010)

ENZYMATIC RING EXPANSION OF PENICILLINS TO CEPHALOSPORINS - SIDE-CHAIN SPECIFICITY
gan: Baldwin, J, et al.
Cyhoeddwyd: (1987)

The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography.
gan: Daruzzaman, A, et al.
Cyhoeddwyd: (2013)

X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis
gan: Rabe, P, et al.
Cyhoeddwyd: (2021)

Production of functionally active <it>Penicillium chrysogenum </it>isopenicillin N synthase in the yeast <it>Hansenula polymorpha</it>
gan: Veenhuis Marten, et al.
Cyhoeddwyd: (2008-03-01)

Photoaffinity labelling of isopenicillin N synthetase by laser-flash photolysis.
gan: Baldwin, J, et al.
Cyhoeddwyd: (1989)

Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase
gan: Rabe, P, et al.
Cyhoeddwyd: (2022)

The crystal structure of isopenicillin N synthase with δ-((L)-α-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron.
gan: Clifton, I, et al.
Cyhoeddwyd: (2011)

CLEAVAGE OF THE 5-AMINO-5-CARBOXY-2-OXAPENTANOYL SIDE-CHAIN FROM ENZYMATICALLY SYNTHESIZED PENICILLINS AND CEPHALOSPORINS
gan: Baldwin, J, et al.
Cyhoeddwyd: (1995)

Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase.
gan: Dubus, A, et al.
Cyhoeddwyd: (2001)

Terminally truncated isopenicillin N synthase generates a dithioester product: evidence for a thioaldehyde intermediate during catalysis and a new mode of reaction for non-heme iron oxidases
gan: McNeill, LA, et al.
Cyhoeddwyd: (2017)