Studies on side chain interactions during the isopenicillin N synthase catalysed biosynthesis of penicillins

The role of the L-δ-(α-aminoadipoyl)-L-cysteinyl amide bond in isopenicillin N synthase catalysis is probed by the synthesis of two analogues of its tripeptide substrate L-δ-α-aminoadipoyl-L-cysteinyl-D-valine.

Bibliografiska uppgifter
Huvudupphovsmän:	Cavelier, F, Russell, A, Schofield, C, Baldwin, J
Materialtyp:	Journal article
Språk:	English
Publicerad:	1997

Liknande verk

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
av: Roach, P, et al.
Publicerad: (1997)

EXAFS STUDIES OF ISOPENICILLIN-N SYNTHASE
av: Randall, C, et al.
Publicerad: (1992)

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
av: Baldwin, J, et al.
Publicerad: (1991)

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
av: Baldwin, J, et al.
Publicerad: (1992)

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in ß-lactam biosynthesis
av: Rabe, P, et al.
Publicerad: (2018)

FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE
av: Baldwin, J, et al.
Publicerad: (1989)

GAMMA-LACTAM FORMATION FROM TRIPEPTIDES WITH ISOPENICILLIN-N SYNTHASE
av: Baldwin, J, et al.
Publicerad: (1988)

Molecular weight analysis of isopenicillin N synthase by electrospray mass spectrometry.
av: Aplin, RT, et al.
Publicerad: (1990)

Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans.
av: Sami, M, et al.
Publicerad: (1997)

Mechanistic studies on isopenicillin n synthase
av: Abbott, S
Publicerad: (1991)

Studies of isopenicillin N synthase enzymatic properties using a continuous spectrophotometric assay.
av: Dubus, A, et al.
Publicerad: (2000)

The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.
av: Daruzzaman, A, et al.
Publicerad: (2013)

Crystallization and preliminary X-ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans.
av: Roach, P, et al.
Publicerad: (1995)

SIDE-CHAIN SPECIFICITY IN THE ENZYMATIC-SYNTHESIS OF PENICILLINS
av: Baldwin, J, et al.
Publicerad: (1990)

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
av: Roach, P, et al.
Publicerad: (1995)

Modification of iron binding ligands in isopenicillin n synthase
av: Sami, M, et al.
Publicerad: (1998)

Crystallization and preliminary X-ray diffraction studies on a recombinant isopenicillin N synthase from Cephalosporium acremonium.
av: Fujishima, Y, et al.
Publicerad: (1994)

X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes.
av: Randall, C, et al.
Publicerad: (1993)

Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies.
av: Roach, P, et al.
Publicerad: (1996)

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.
av: Ge, W, et al.
Publicerad: (2010)

THE FATE OF VALINE-OXYGEN DURING PENICILLIN BIOSYNTHESIS
av: Baldwin, J, et al.
Publicerad: (1989)

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.
av: Ge, W, et al.
Publicerad: (2010)

Photoaffinity labelling of isopenicillin N synthetase.
av: Baldwin, J, et al.
Publicerad: (1990)

Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue.
av: Ge, W, et al.
Publicerad: (2009)

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.
av: Long, A, et al.
Publicerad: (2003)

THE ENZYMATIC RING EXPANSION OF PENICILLINS TO CEPHALOSPORINS - SIDE-CHAIN SPECIFICITY
av: Baldwin, J, et al.
Publicerad: (1987)

Proteins of the penicillin biosynthesis pathway.
av: Schofield, C, et al.
Publicerad: (1997)

Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles.
av: Hamed, R, et al.
Publicerad: (2010)

Anaerobic crystallisation of an isopenicillin N synthase center dot Fe(II)center dot substrate complex demonstrated by X-ray studies
av: Roach, P, et al.
Publicerad: (1996)

ENZYMATIC RING EXPANSION OF PENICILLINS TO CEPHALOSPORINS - SIDE-CHAIN SPECIFICITY
av: Baldwin, J, et al.
Publicerad: (1987)

The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography.
av: Daruzzaman, A, et al.
Publicerad: (2013)

X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis
av: Rabe, P, et al.
Publicerad: (2021)

Photoaffinity labelling of isopenicillin N synthetase by laser-flash photolysis.
av: Baldwin, J, et al.
Publicerad: (1989)

Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase
av: Rabe, P, et al.
Publicerad: (2022)

Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase.
av: Dubus, A, et al.
Publicerad: (2001)

CLEAVAGE OF THE 5-AMINO-5-CARBOXY-2-OXAPENTANOYL SIDE-CHAIN FROM ENZYMATICALLY SYNTHESIZED PENICILLINS AND CEPHALOSPORINS
av: Baldwin, J, et al.
Publicerad: (1995)

The crystal structure of isopenicillin N synthase with δ-((L)-α-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron.
av: Clifton, I, et al.
Publicerad: (2011)

Terminally truncated isopenicillin N synthase generates a dithioester product: evidence for a thioaldehyde intermediate during catalysis and a new mode of reaction for non-heme iron oxidases
av: McNeill, LA, et al.
Publicerad: (2017)

PENICILLIN BIOSYNTHESIS - STEREOCHEMICAL DEPENDENCE ON MODE OF 2ND RING-CLOSURE
av: Baldwin, J, et al.
Publicerad: (1989)

Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms.
av: Clifton, I, et al.
Publicerad: (2011)