Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults: a 10-year cohort
<p><strong>Objective</strong> To examine the associations of individual insomnia symptoms with risks of incident cardio-cerebral vascular diseases (CVD) and possible moderating factors among Chinese adults.</p> <p><strong>Methods</strong> The China Kadoorie...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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American Academy of Neurology
2019
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| _version_ | 1797066263334223872 |
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| author | Zheng, B Yu, C Lv, J Guo, Y Bian, Z Zhou, M Yang, L Chen, Y Li, X Zou, J Ning, F Chen, J Chen, Z Li, L China Kadoorie Biobank Collaborative Group |
| author_facet | Zheng, B Yu, C Lv, J Guo, Y Bian, Z Zhou, M Yang, L Chen, Y Li, X Zou, J Ning, F Chen, J Chen, Z Li, L China Kadoorie Biobank Collaborative Group |
| author_sort | Zheng, B |
| collection | OXFORD |
| description | <p><strong>Objective</strong> To examine the associations of individual insomnia symptoms with risks of incident cardio-cerebral vascular diseases (CVD) and possible moderating factors among Chinese adults.</p> <p><strong>Methods</strong> The China Kadoorie Biobank is a prospective cohort study that recruited participants from 10 areas across China. Data from 487,200 adults 30 to 79 years of age who were free of stroke, coronary heart disease, and cancer at baseline were analyzed. Three insomnia symptoms were assessed with self-reported difficulties in initiating or maintaining sleep, early morning awakening, and daytime dysfunction for at least 3 d/wk at baseline. Incidences of CVD were followed up through disease registries and national health insurance databases until 2016.</p> <p><strong>Results</strong> During a median of 9.6 years of follow-up, 130,032 cases of CVD were documented. Cox regressions showed that 3 insomnia symptoms were associated with increased risk of total CVD, with respective adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of 1.09 (95% CI 1.07–1.11), 1.07 (95% CI 1.05–1.09), and 1.13 (95% CI 1.09–1.18). Participants with individual symptoms also had higher risks of ischemic heart disease (IHD; HR 1.13, 1.09, and 1.17) and ischemic stroke but not hemorrhagic stroke. Participants with all 3 symptoms were at an 18%, 22%, or 10% higher risk of CVD, IHD, or ischemic stroke compared to nonsymptomatic adults. Associations between 3 symptoms and CVD incidence were consistently stronger in younger adults or those without baseline hypertension (p for interaction <0.05).</p> <p><strong>Conclusions</strong> Individual and coexisting insomnia symptoms are independent risk factors for CVD incidence, especially among young adults or adults who have not developed hypertension.</p> |
| first_indexed | 2024-03-06T21:39:57Z |
| format | Journal article |
| id | oxford-uuid:4793142b-9635-4cff-b579-899a5603942c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:39:57Z |
| publishDate | 2019 |
| publisher | American Academy of Neurology |
| record_format | dspace |
| spelling | oxford-uuid:4793142b-9635-4cff-b579-899a5603942c2022-03-26T15:20:55ZInsomnia symptoms and risk of cardiovascular diseases among 0.5 million adults: a 10-year cohortJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4793142b-9635-4cff-b579-899a5603942cEnglishSymplectic Elements at OxfordAmerican Academy of Neurology2019Zheng, BYu, CLv, JGuo, YBian, ZZhou, MYang, LChen, YLi, XZou, JNing, FChen, JChen, ZLi, LChina Kadoorie Biobank Collaborative Group<p><strong>Objective</strong> To examine the associations of individual insomnia symptoms with risks of incident cardio-cerebral vascular diseases (CVD) and possible moderating factors among Chinese adults.</p> <p><strong>Methods</strong> The China Kadoorie Biobank is a prospective cohort study that recruited participants from 10 areas across China. Data from 487,200 adults 30 to 79 years of age who were free of stroke, coronary heart disease, and cancer at baseline were analyzed. Three insomnia symptoms were assessed with self-reported difficulties in initiating or maintaining sleep, early morning awakening, and daytime dysfunction for at least 3 d/wk at baseline. Incidences of CVD were followed up through disease registries and national health insurance databases until 2016.</p> <p><strong>Results</strong> During a median of 9.6 years of follow-up, 130,032 cases of CVD were documented. Cox regressions showed that 3 insomnia symptoms were associated with increased risk of total CVD, with respective adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of 1.09 (95% CI 1.07–1.11), 1.07 (95% CI 1.05–1.09), and 1.13 (95% CI 1.09–1.18). Participants with individual symptoms also had higher risks of ischemic heart disease (IHD; HR 1.13, 1.09, and 1.17) and ischemic stroke but not hemorrhagic stroke. Participants with all 3 symptoms were at an 18%, 22%, or 10% higher risk of CVD, IHD, or ischemic stroke compared to nonsymptomatic adults. Associations between 3 symptoms and CVD incidence were consistently stronger in younger adults or those without baseline hypertension (p for interaction <0.05).</p> <p><strong>Conclusions</strong> Individual and coexisting insomnia symptoms are independent risk factors for CVD incidence, especially among young adults or adults who have not developed hypertension.</p> |
| spellingShingle | Zheng, B Yu, C Lv, J Guo, Y Bian, Z Zhou, M Yang, L Chen, Y Li, X Zou, J Ning, F Chen, J Chen, Z Li, L China Kadoorie Biobank Collaborative Group Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults: a 10-year cohort |
| title | Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults: a 10-year cohort |
| title_full | Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults: a 10-year cohort |
| title_fullStr | Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults: a 10-year cohort |
| title_full_unstemmed | Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults: a 10-year cohort |
| title_short | Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults: a 10-year cohort |
| title_sort | insomnia symptoms and risk of cardiovascular diseases among 0 5 million adults a 10 year cohort |
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