SNP-based heritability estimates of common and specific variance in self- and informant-reported neuroticism scales.
<h4>Objective</h4> <p>Our study aims to estimate the proportion of the phenotypic variance of Neuroticism and its facet scales that can be attributed to common single-nucleotide polymorphisms (SNPs) in two adult populations from Estonia (EGCUT; N53,292) and the Netherlands (Lifeli...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Wiley
2016
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| _version_ | 1826270390113009664 |
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| author | Realo, A van der Most, P Allik, J Esko, T Jeronimus, B Kööts-Ausmees, L Mõttus, R Tropf, F Snieder, H Ormel, J |
| author_facet | Realo, A van der Most, P Allik, J Esko, T Jeronimus, B Kööts-Ausmees, L Mõttus, R Tropf, F Snieder, H Ormel, J |
| author_sort | Realo, A |
| collection | OXFORD |
| description | <h4>Objective</h4> <p>Our study aims to estimate the proportion of the phenotypic variance of Neuroticism and its facet scales that can be attributed to common single-nucleotide polymorphisms (SNPs) in two adult populations from Estonia (EGCUT; N53,292) and the Netherlands (Lifelines; N513,383).</p> <h4>Method</h4> <p>Genomic-relatedness-matrix restricted maximum likelihood (GREML) using genome-wide complex trait analysis (GCTA) software was employed. To build upon previous research, we used self- and informant reports of the 30-facet NEO personality inventories and analyzed both the usual sum scores and the residual facet scores of Neuroticism.</p> <h4>Results</h4> <p>In the EGCUT cohort, the proportion of phenotypic variance explained by the additive effects of common genetic variants in self- and informant-reported Neuroticism domain scores was 15.2% (p5.070, SE5.11) and 6.2% (p5.293, SE5.12), respectively. The SNP-based heritability estimates at the level of Neuroticism facet scales differed greatly across cohorts and modes of measurement but were generally higher (a) for self- than for informant reports, and (b) for sum than for residual scores.</p> <h4>Conclusions</h4> <p>Our findings indicate that a large proportion of the heritability of Neuroticism is not captured by additive genetic effects of common SNPs, with some evidence for Gene 3 Environment interaction across cohorts.</p> |
| first_indexed | 2024-03-06T21:40:04Z |
| format | Journal article |
| id | oxford-uuid:479ac05b-2764-4874-959a-633c038b01c5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:40:04Z |
| publishDate | 2016 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:479ac05b-2764-4874-959a-633c038b01c52022-03-26T15:21:05ZSNP-based heritability estimates of common and specific variance in self- and informant-reported neuroticism scales.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:479ac05b-2764-4874-959a-633c038b01c5EnglishSymplectic Elements at OxfordWiley2016Realo, Avan der Most, PAllik, JEsko, TJeronimus, BKööts-Ausmees, LMõttus, RTropf, FSnieder, HOrmel, J <h4>Objective</h4> <p>Our study aims to estimate the proportion of the phenotypic variance of Neuroticism and its facet scales that can be attributed to common single-nucleotide polymorphisms (SNPs) in two adult populations from Estonia (EGCUT; N53,292) and the Netherlands (Lifelines; N513,383).</p> <h4>Method</h4> <p>Genomic-relatedness-matrix restricted maximum likelihood (GREML) using genome-wide complex trait analysis (GCTA) software was employed. To build upon previous research, we used self- and informant reports of the 30-facet NEO personality inventories and analyzed both the usual sum scores and the residual facet scores of Neuroticism.</p> <h4>Results</h4> <p>In the EGCUT cohort, the proportion of phenotypic variance explained by the additive effects of common genetic variants in self- and informant-reported Neuroticism domain scores was 15.2% (p5.070, SE5.11) and 6.2% (p5.293, SE5.12), respectively. The SNP-based heritability estimates at the level of Neuroticism facet scales differed greatly across cohorts and modes of measurement but were generally higher (a) for self- than for informant reports, and (b) for sum than for residual scores.</p> <h4>Conclusions</h4> <p>Our findings indicate that a large proportion of the heritability of Neuroticism is not captured by additive genetic effects of common SNPs, with some evidence for Gene 3 Environment interaction across cohorts.</p> |
| spellingShingle | Realo, A van der Most, P Allik, J Esko, T Jeronimus, B Kööts-Ausmees, L Mõttus, R Tropf, F Snieder, H Ormel, J SNP-based heritability estimates of common and specific variance in self- and informant-reported neuroticism scales. |
| title | SNP-based heritability estimates of common and specific variance in self- and informant-reported neuroticism scales. |
| title_full | SNP-based heritability estimates of common and specific variance in self- and informant-reported neuroticism scales. |
| title_fullStr | SNP-based heritability estimates of common and specific variance in self- and informant-reported neuroticism scales. |
| title_full_unstemmed | SNP-based heritability estimates of common and specific variance in self- and informant-reported neuroticism scales. |
| title_short | SNP-based heritability estimates of common and specific variance in self- and informant-reported neuroticism scales. |
| title_sort | snp based heritability estimates of common and specific variance in self and informant reported neuroticism scales |
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