Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34+ progenitor cells

Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34+ progenitor cells

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The ASXL1 gene encodes a chromatin-binding protein involved in epigenetic regulation in haematopoietic cells. Loss-of-function ASXL1 mutations occur in patients with a range of myeloid malignancies and are associated with adverse outcome. We have used lentiviral-based shRNA technology to investigate...

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Bibliographic Details
Main Authors:	Davies, C, Yip, B, Fernandez-Mercado, M, Woll, P, Agirre, X, Prosper, F, Jacobsen, SE, Wainscoat, J, Pellagatti, A, Boultwood, J
Format:	Journal article
Language:	English
Published:	2013

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