ATP-sensitive K+ channels in human isolated pancreatic B-cells.
Glucose-stimulated insulin release from rodent pancreatic B-cells is thought to be initiated by the closing of ATP-sensitive K+ channels in the plasma membrane as a consequence of glucose metabolism. We have identified an ATP-sensitive K+ channel in membrane patches excised from human B-cells which...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1987
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| _version_ | 1826270426008911872 |
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| author | Ashcroft, F Kakei, M Kelly, R Sutton, R |
| author_facet | Ashcroft, F Kakei, M Kelly, R Sutton, R |
| author_sort | Ashcroft, F |
| collection | OXFORD |
| description | Glucose-stimulated insulin release from rodent pancreatic B-cells is thought to be initiated by the closing of ATP-sensitive K+ channels in the plasma membrane as a consequence of glucose metabolism. We have identified an ATP-sensitive K+ channel in membrane patches excised from human B-cells which is similar to that found in rodent B-cells in conductance, kinetics, ATP sensitivity and its inhibition by sulphonylureas. In man, the ATP-sensitive K+ channel may also have a central role in glucose-stimulated insulin secretion and may be (linked to) the receptor for the hypoglycemic sulphonylureas. |
| first_indexed | 2024-03-06T21:40:38Z |
| format | Journal article |
| id | oxford-uuid:47d0139c-76ed-4b2c-bbe0-b21fb7054275 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:40:38Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:47d0139c-76ed-4b2c-bbe0-b21fb70542752022-03-26T15:22:07ZATP-sensitive K+ channels in human isolated pancreatic B-cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:47d0139c-76ed-4b2c-bbe0-b21fb7054275EnglishSymplectic Elements at Oxford1987Ashcroft, FKakei, MKelly, RSutton, RGlucose-stimulated insulin release from rodent pancreatic B-cells is thought to be initiated by the closing of ATP-sensitive K+ channels in the plasma membrane as a consequence of glucose metabolism. We have identified an ATP-sensitive K+ channel in membrane patches excised from human B-cells which is similar to that found in rodent B-cells in conductance, kinetics, ATP sensitivity and its inhibition by sulphonylureas. In man, the ATP-sensitive K+ channel may also have a central role in glucose-stimulated insulin secretion and may be (linked to) the receptor for the hypoglycemic sulphonylureas. |
| spellingShingle | Ashcroft, F Kakei, M Kelly, R Sutton, R ATP-sensitive K+ channels in human isolated pancreatic B-cells. |
| title | ATP-sensitive K+ channels in human isolated pancreatic B-cells. |
| title_full | ATP-sensitive K+ channels in human isolated pancreatic B-cells. |
| title_fullStr | ATP-sensitive K+ channels in human isolated pancreatic B-cells. |
| title_full_unstemmed | ATP-sensitive K+ channels in human isolated pancreatic B-cells. |
| title_short | ATP-sensitive K+ channels in human isolated pancreatic B-cells. |
| title_sort | atp sensitive k channels in human isolated pancreatic b cells |
| work_keys_str_mv | AT ashcroftf atpsensitivekchannelsinhumanisolatedpancreaticbcells AT kakeim atpsensitivekchannelsinhumanisolatedpancreaticbcells AT kellyr atpsensitivekchannelsinhumanisolatedpancreaticbcells AT suttonr atpsensitivekchannelsinhumanisolatedpancreaticbcells |