Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML).

Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML).

Strategies that augment a GVL effect without increasing the risk of GVHD are required to improve the outcome after allogeneic stem cell transplantation (SCT). Azacitidine (AZA) up-regulates the expression of tumor Ags on leukemic blasts in vitro and expands the numbers of immunomodulatory T regulato...

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Autors principals: Goodyear, O, Dennis, M, Jilani, N, Loke, J, Siddique, S, Ryan, G, Nunnick, J, Khanum, R, Raghavan, M, Cook, M, Snowden, J, Griffiths, M, Russell, N, Yin, J, Crawley, C, Cook, G, Vyas, P, Moss, P, Malladi, R, Craddock, C
Format: Journal article
Idioma:English
Publicat: 2012

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