The effects of oral almitrine on pattern of breathing and gas exchange in patients with chronic obstructive pulmonary disease.
Almitrine at a low dose of 100 mg orally significantly raises PaO2 and lowers PaCO2 in patients with chronic obstructive pulmonary disease, compared with placebo, when they were breathing air or 28% oxygen. The estimated ideal alveolar-arterial PO2 difference was less after almitrine compared with p...
| Автори: | , , , , , |
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| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
1984
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| _version_ | 1826270435685171200 |
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| author | Stradling, JR Nicholl, C Cover, D Davies, E Hughes, J Pride, N |
| author_facet | Stradling, JR Nicholl, C Cover, D Davies, E Hughes, J Pride, N |
| author_sort | Stradling, JR |
| collection | OXFORD |
| description | Almitrine at a low dose of 100 mg orally significantly raises PaO2 and lowers PaCO2 in patients with chronic obstructive pulmonary disease, compared with placebo, when they were breathing air or 28% oxygen. The estimated ideal alveolar-arterial PO2 difference was less after almitrine compared with placebo, when patients were breathing either air or 28% oxygen. After almitrine overall ventilation breathing air increased by 10% but this did not reach statistical significance. During 28% oxygen breathing almitrine hardly altered overall ventilation but the inspiratory duty cycle (Ti/Ttot.) decreased and mean inspiratory flow rate (VT/Ti) increased compared with placebo. These changes were significant on a paired t-test (P less than 0.05). Changes in both volume and pattern of breathing may explain the improved gas exchange in the lung after almitrine. |
| first_indexed | 2024-03-06T21:40:47Z |
| format | Journal article |
| id | oxford-uuid:47d82509-5b5a-43d0-a183-a544a9924d00 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:40:47Z |
| publishDate | 1984 |
| record_format | dspace |
| spelling | oxford-uuid:47d82509-5b5a-43d0-a183-a544a9924d002022-03-26T15:22:23ZThe effects of oral almitrine on pattern of breathing and gas exchange in patients with chronic obstructive pulmonary disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:47d82509-5b5a-43d0-a183-a544a9924d00EnglishSymplectic Elements at Oxford1984Stradling, JRNicholl, CCover, DDavies, EHughes, JPride, NAlmitrine at a low dose of 100 mg orally significantly raises PaO2 and lowers PaCO2 in patients with chronic obstructive pulmonary disease, compared with placebo, when they were breathing air or 28% oxygen. The estimated ideal alveolar-arterial PO2 difference was less after almitrine compared with placebo, when patients were breathing either air or 28% oxygen. After almitrine overall ventilation breathing air increased by 10% but this did not reach statistical significance. During 28% oxygen breathing almitrine hardly altered overall ventilation but the inspiratory duty cycle (Ti/Ttot.) decreased and mean inspiratory flow rate (VT/Ti) increased compared with placebo. These changes were significant on a paired t-test (P less than 0.05). Changes in both volume and pattern of breathing may explain the improved gas exchange in the lung after almitrine. |
| spellingShingle | Stradling, JR Nicholl, C Cover, D Davies, E Hughes, J Pride, N The effects of oral almitrine on pattern of breathing and gas exchange in patients with chronic obstructive pulmonary disease. |
| title | The effects of oral almitrine on pattern of breathing and gas exchange in patients with chronic obstructive pulmonary disease. |
| title_full | The effects of oral almitrine on pattern of breathing and gas exchange in patients with chronic obstructive pulmonary disease. |
| title_fullStr | The effects of oral almitrine on pattern of breathing and gas exchange in patients with chronic obstructive pulmonary disease. |
| title_full_unstemmed | The effects of oral almitrine on pattern of breathing and gas exchange in patients with chronic obstructive pulmonary disease. |
| title_short | The effects of oral almitrine on pattern of breathing and gas exchange in patients with chronic obstructive pulmonary disease. |
| title_sort | effects of oral almitrine on pattern of breathing and gas exchange in patients with chronic obstructive pulmonary disease |
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