Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals.
The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2013
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| _version_ | 1797066358484107264 |
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| author | Zhang, Y Zhao, Y Li, N Peng, Y Giannoulatou, E Jin, R Yan, H Wu, H Liu, J Liu, N Wang, D Shu, Y Ho, L Kellam, P McMichael, A Dong, T |
| author_facet | Zhang, Y Zhao, Y Li, N Peng, Y Giannoulatou, E Jin, R Yan, H Wu, H Liu, J Liu, N Wang, D Shu, Y Ho, L Kellam, P McMichael, A Dong, T |
| author_sort | Zhang, Y |
| collection | OXFORD |
| description | The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent. |
| first_indexed | 2024-03-06T21:40:53Z |
| format | Journal article |
| id | oxford-uuid:47e366b6-05c8-4de9-a31d-c6f2a0db0d18 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:40:53Z |
| publishDate | 2013 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:47e366b6-05c8-4de9-a31d-c6f2a0db0d182022-03-26T15:22:36ZInterferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:47e366b6-05c8-4de9-a31d-c6f2a0db0d18EnglishSymplectic Elements at OxfordSpringer Nature2013Zhang, YZhao, YLi, NPeng, YGiannoulatou, EJin, RYan, HWu, HLiu, JLiu, NWang, DShu, YHo, LKellam, PMcMichael, ADong, TThe SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent. |
| spellingShingle | Zhang, Y Zhao, Y Li, N Peng, Y Giannoulatou, E Jin, R Yan, H Wu, H Liu, J Liu, N Wang, D Shu, Y Ho, L Kellam, P McMichael, A Dong, T Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. |
| title | Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. |
| title_full | Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. |
| title_fullStr | Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. |
| title_full_unstemmed | Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. |
| title_short | Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. |
| title_sort | interferon induced transmembrane protein 3 genetic variant rs12252 c is associated with severe influenza in chinese individuals |
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