Structural basis of fumarate hydratase deficiency.

Structural basis of fumarate hydratase deficiency.

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Fumarate hydratase catalyzes the stereospecific hydration across the olefinic double bond in fumarate leading to L-malate. The enzyme is expressed in mitochondrial and cytosolic compartments, and participates in the Krebs cycle in mitochondria, as well as in regulation of cytosolic fumarate levels....

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Dettagli Bibliografici
Autori principali:	Picaud, S, Kavanagh, K, Yue, W, Lee, W, Muller-Knapp, S, Gileadi, O, Sacchettini, J, Oppermann, U
Natura:	Journal article
Lingua:	English
Pubblicazione:	2011

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