PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development.

PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development.

Upon fertilisation by sperm, mammalian eggs are activated by a series of intracellular Ca(2+) oscillations that are essential for embryo development. The mechanism by which sperm induces this complex signalling phenomenon is unknown. One proposal is that the sperm introduces an exclusive cytosolic f...

Full description

Bibliographic Details
Main Authors:	Saunders, C, Larman, MG, Parrington, J, Cox, L, Royse, J, Blayney, L, Swann, K, Lai, F
Format:	Journal article
Language:	English
Published:	2002

Similar Items

PLCζ: A sperm-specific trigger of Ca2+ oscillations in eggs and embryo development
by: Saunders, C, et al.
Published: (2002)

Human sperm devoid of PLC, zeta 1 fail to induce Ca(2+) release and are unable to initiate the first step of embryo development.
by: Yoon, S, et al.
Published: (2008)

Potential role of a sperm-derived phospholipase C in triggering the egg-activating Ca2+ signal at fertilization.
by: Swann, K, et al.
Published: (2001)

Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update
by: Alaaeldin Saleh, et al.
Published: (2020-01-01)

Sperm-Induced Ca<sup>2+</sup> Release in Mammalian Eggs: The Roles of PLCζ, InsP<sub>3</sub>, and ATP
by: Karl Swann
Published: (2023-12-01)

Identification and functional analysis of an ovarian form of the egg activation factor phospholipase C Zeta (PLCζ) in pufferfish.
by: Coward, K, et al.
Published: (2010)

Identification and functional analysis of an ovarian form of the egg activation factor phospholipase C zeta (PLCζ) in pufferfish.
by: Coward, K, et al.
Published: (2011)

Phospholipase C isoforms in mammalian spermatozoa: potential components of the sperm factor that causes Ca2+ release in eggs.
by: Parrington, J, et al.
Published: (2002)

PLCζ is the physiological trigger of the Ca(2+) oscillations that induce embryogenesis in mammals but offspring can be conceived in its absence
by: Hachem, A, et al.
Published: (2017)

Isolation and identification of PLC-zeta (a sperm factor protein responsible for embryonic development) in paddy rats.
by: Sukardi, Sabrina, et al.
Published: (2008)

Expression of recombinant PLC4 in mouse sperm
by: Kubota, H, et al.
Published: (2008)

PLCζ and its role as a trigger of development in vertebrates.
by: Ito, J, et al.
Published: (2011)

PLCζ Induced Ca2+ Oscillations in Mouse Eggs Involve a Positive Feedback Cycle of Ca2+ Induced InsP3 Formation From Cytoplasmic PIP2
by: Jessica R. Sanders, et al.
Published: (2018-04-01)

Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCζ) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells.
by: Kashir, J, et al.
Published: (2012)

Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCζ) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells
by: Kashir, J, et al.
Published: (2012)

Extraction of total RNA from sperm of New Zealand white rabbits for detection of phospholipase C zeta (PLC ζ)
by: Samsul Baharil, Nur Hayati, et al.
Published: (2015)

Teleost fish spermatozoa contain a cytosolic protein factor that induces calcium release in sea urchin egg homogenates and triggers calcium oscillations when injected into mouse oocytes.
by: Coward, K, et al.
Published: (2003)

Does advancing male age influence the expression levels and localisation patterns of phospholipase C zeta (PLCζ) in human sperm?
by: Yeste, M, et al.
Published: (2016)

Does advancing male age influence the expression levels and localisation patterns of phospholipase C zeta (PLCζ) in human sperm?
by: Yeste, M., et al.
Published: (2016)

The clinical diagnosis and treatment of phospholipase C zeta (PLCζ) deficiency and the development of a nanoparticle-mediated delivery method for sperm
by: Galal, S
Published: (2024)

Phospholipase C zeta undergoes dynamic changes in its pattern of localization in sperm during capacitation and the acrosome reaction.
by: Young, C, et al.
Published: (2009)

Phospholipase C zeta undergoes dynamic changes in its pattern of localization in sperm during capacitation and the acrosome reaction
by: Young, C, et al.
Published: (2009)

Flipping the switch: how a sperm activates the egg at fertilization.
by: Parrington, J, et al.
Published: (2007)

Expression of a fluorescent recombinant form of sperm protein phospholipase C zeta in mouse epididymal sperm by in vivo gene transfer into the testis.
by: Coward, K, et al.
Published: (2006)

Calcium (ca2+) oscillations and intensity in fresh embryo and vitrified embryos produced from intra-cytoplasmic sperm injection (isci)
by: Widjiati WIDJIATI, et al.
Published: (2021-11-01)

A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility.
by: Kashir, J, et al.
Published: (2012)

Developmental Enhancement of Intracytoplasmic Sperm Injection (ICSI)-Generated Quail Embryos by Phospholipase Cζ cRNA
by: Shusei Mizushima, et al.
Published: (2008-04-01)

Phospholipase C zeta (PLCζ) and the clinical diagnosis of oocyte activation deficiency
by: Jones, C, et al.
Published: (2022)

Mammalian sperm contain a Ca(2+)-sensitive phospholipase C activity that can generate InsP(3) from PIP(2) associated with intracellular organelles.
by: Rice, A, et al.
Published: (2000)

Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes.
by: Kashir, J, et al.
Published: (2011)

Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes
by: Kashir, J, et al.
Published: (2011)

Eggs sorting machine using PLC/
by: 438599 Leu Ming
Published: (1991)

IP3-Dependent Ca2+ Oscillations Switch into a Dual Oscillator Mechanism in the Presence of PLC-Linked Hormones
by: Paula J. Bartlett, et al.
Published: (2020-05-01)

OSCILLATIONS IN V(ZETA) CURVES OF THIN SAMPLES
by: Mutti, P, et al.
Published: (1995)

Acceptance of donor eggs, donor sperms, or donor embryos in Indian infertile couples
by: Kaberi Banerjee, et al.
Published: (2018-01-01)

Mammalian sperm contain a Ca2+-sensitive phospholipase C activity that can generate InsP(3) from PIP2 associated with intracellular organelles (vol 228, pg 125, 2000)
by: Rice, A, et al.
Published: (2001)

Artificial oocyte activation (AOA) and phospholipase C zeta (PLCζ) in assisted reproductive technology (ART)
by: Meng, X
Published: (2019)

Oocyte activation and phospholipase C zeta (PLCζ): diagnostic and therapeutic implications for assisted reproductive technology
by: Ramadan Walaa M, et al.
Published: (2012-07-01)

Attitudes of sperm, egg and embryo donors and recipients towards genetic information and screening of donors
by: David J. Amor, et al.
Published: (2018-02-01)

Zn2+ is essential for Ca2+ oscillations in mouse eggs
by: Hiroki Akizawa, et al.
Published: (2023-12-01)