Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation
Alanine-serine-cysteine transporter 2 (ASCT2, SLC1A5) is the primary transporter of glutamine in cancer cells and regulates the mTORC1 signaling pathway. The SLC1A5 function involves finely tuned orchestration of two domain movements that include the substrate-binding transport domain and the scaffo...
Main Authors: | Yu, X, Plotnikova, O, Bonin, P, Subashi, T, McLellan, T, Dumlao, D, Che, Y, Dong, Y, Carpenter, E, West, G, Qiu, X, Culp, J, Han, S |
---|---|
Format: | Journal article |
Language: | English |
Published: |
eLife Sciences Publications
2019
|
Similar Items
-
Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations
by: Jing Xue, et al.
Published: (2020-07-01) -
CryoEM structures of anion exchanger 1 capture multiple states of inward- and outward-facing conformations
by: Hristina R. Zhekova, et al.
Published: (2022-12-01) -
Dynamics of a bacterial multidrug ABC transporter in the inward- and outward-facing conformations.
by: Mehmood, S, et al.
Published: (2012) -
D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures.
by: Alan C Foster, et al.
Published: (2016-01-01) -
Revealing an outward-facing open conformational state in a CLC Cl–/H+ exchange transporter
by: Chandra M Khantwal, et al.
Published: (2016-01-01)