Multi-molecule reaction of serum albumin can occur through thiol-yne coupling.
The free-radical hydrothiolation of alkynes (thiol-yne coupling, TYC) unites two thiol fragments across the carbon-carbon triple bond to give a dithioether derivative with exclusive 1,2-addition; this reaction can be used for modification of peptides and proteins allowing glycoconjugation and fluore...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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| _version_ | 1826270494753554432 |
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| author | Lo Conte, M Staderini, S Marra, A Sanchez-Navarro, M Davis, B Dondoni, A |
| author_facet | Lo Conte, M Staderini, S Marra, A Sanchez-Navarro, M Davis, B Dondoni, A |
| author_sort | Lo Conte, M |
| collection | OXFORD |
| description | The free-radical hydrothiolation of alkynes (thiol-yne coupling, TYC) unites two thiol fragments across the carbon-carbon triple bond to give a dithioether derivative with exclusive 1,2-addition; this reaction can be used for modification of peptides and proteins allowing glycoconjugation and fluorescent labeling. These results have implications not only as a flexible strategy for attaching two modifications at a single site in proteins but also for unanticipated side-reactions of reagents (such as cycloalkynes) used in other protein coupling reactions. |
| first_indexed | 2024-03-06T21:41:40Z |
| format | Journal article |
| id | oxford-uuid:4827fdc0-fe6e-4bb5-be4a-bc82c23449d3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:41:40Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:4827fdc0-fe6e-4bb5-be4a-bc82c23449d32022-03-26T15:24:00ZMulti-molecule reaction of serum albumin can occur through thiol-yne coupling.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4827fdc0-fe6e-4bb5-be4a-bc82c23449d3EnglishSymplectic Elements at Oxford2011Lo Conte, MStaderini, SMarra, ASanchez-Navarro, MDavis, BDondoni, AThe free-radical hydrothiolation of alkynes (thiol-yne coupling, TYC) unites two thiol fragments across the carbon-carbon triple bond to give a dithioether derivative with exclusive 1,2-addition; this reaction can be used for modification of peptides and proteins allowing glycoconjugation and fluorescent labeling. These results have implications not only as a flexible strategy for attaching two modifications at a single site in proteins but also for unanticipated side-reactions of reagents (such as cycloalkynes) used in other protein coupling reactions. |
| spellingShingle | Lo Conte, M Staderini, S Marra, A Sanchez-Navarro, M Davis, B Dondoni, A Multi-molecule reaction of serum albumin can occur through thiol-yne coupling. |
| title | Multi-molecule reaction of serum albumin can occur through thiol-yne coupling. |
| title_full | Multi-molecule reaction of serum albumin can occur through thiol-yne coupling. |
| title_fullStr | Multi-molecule reaction of serum albumin can occur through thiol-yne coupling. |
| title_full_unstemmed | Multi-molecule reaction of serum albumin can occur through thiol-yne coupling. |
| title_short | Multi-molecule reaction of serum albumin can occur through thiol-yne coupling. |
| title_sort | multi molecule reaction of serum albumin can occur through thiol yne coupling |
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